FLO10/YKR102W Summary Help

Standard Name FLO10
Systematic Name YKR102W
Feature Type ORF, Verified
Description Member of the FLO family of cell wall flocculation proteins; not expressed in most lab strains; overproduction induces flocculation that can be inhibited by mannose, sucrose, or glucose; overproduction also promotes haploid invasive growth and diploid filamentous growth (1, 2, 3 and see Summary Paragraph)
Name Description FLOcculation
Chromosomal Location
ChrXI:646356 to 649865 | ORF Map | GBrowse
Gene Ontology Annotations All FLO10 GO evidence and references
  View Computational GO annotations for FLO10
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 5 genes
Classical genetics
Large-scale survey
9 total interaction(s) for 9 unique genes/features.
Genetic Interactions
  • Dosage Growth Defect: 4
  • Negative Genetic: 2
  • Phenotypic Enhancement: 3

Expression Summary
Length (a.a.) 1,169
Molecular Weight (Da) 122,163
Isoelectric Point (pI) 4.06
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrXI:646356 to 649865 | ORF Map | GBrowse
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..3510 646356..649865 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001810

Flocculation, the calcium-dependent, non-sexual aggregation of yeast cells into 'flocs', is stimulated by nutrient limitation and is a process of great importance to the brewing characteristics of yeast strains (1). Characterization of flocculation characteristics has defined two classes of flocculation phenotypes. The FLO1-type is inhibited only by mannose sugars (4). The NewFLO-type, common in brewing strains, is inhibited by the sugars mannose, maltose, glucose, and sucrose, as well as by ammonium ions (4).

Sequence analysis suggests that the flocculation genes are a multi-gene family localized to telomeric sequences, similarly to the SUC, MEL, and MAL gene families, all of which also encode characteristics important for brewing strains (1). In addition to FLO1 and FLO5, there are thought to be two more flocculation genes and three pseudogenes. The FLO9 gene (YAL063C) is 94% similar to the FLO1 gene and may be the source of a 4.2-kb transcript whose presence is not affected by deletions of FLO1 or FLO5. The FLO10 gene (YKR102W) is 58% similar to FLO1, but has 81.9% similarity in the N-terminus (1). Three presumed pseudogenes, YAL065C, YAR061W and YAR062W, and YHR213W have also been identified as fragmentary pieces with sequence similarity to FLO1 (1).

Last updated: 2004-02-09 Contact SGD

References cited on this page View Complete Literature Guide for FLO10
1) Teunissen AW and Steensma HY  (1995) Review: the dominant flocculation genes of Saccharomyces cerevisiae constitute a new subtelomeric gene family. Yeast 11(11):1001-13
2) Guo B, et al.  (2000) A Saccharomyces gene family involved in invasive growth, cell-cell adhesion, and mating. Proc Natl Acad Sci U S A 97(22):12158-63
3) Van Mulders SE, et al.  (2009) Phenotypic diversity of Flo protein family-mediated adhesion in Saccharomyces cerevisiae. FEMS Yeast Res 9(2):178-90
4) Stratford M  (1989) Evidence for two mechanisms of flocculation in Saccharomyces cerevisiae. Yeast 5 Spec No():S441-5