FPR2/YDR519W Summary Help

FPR2 BASIC INFORMATION

Standard Name FPR2
Systematic Name YDR519W
Alias FKB2
Feature Type ORF, Verified
Description Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking (1, 2, 3)
Name Description FKBP Proline Rotamase
GO Annotations All FPR2 GO evidence and references
    View Computational GO annotations for FPR2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All FPR2 Phenotype details and references
Classical genetics
null
Large-scale survey
null
Interactions FPR2 All interactions details and references
10 total interaction(s) for 9 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-RNA: 1
Genetic Interactions
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 3
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 1
Sequence Information
ChrIV:1480418 to 1480825 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2008-06-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..408 1480418..1480825 2008-06-05 1996-07-31
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000002927

FPR2 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
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  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for FPR2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for FPR2]

1) Partaledis JA and Berlin V  (1993) The FKB2 gene of Saccharomyces cerevisiae, encoding the immunosuppressant-binding protein FKBP-13, is regulated in response to accumulation of unfolded proteins in the endoplasmic reticulum. Proc Natl Acad Sci U S A 90(12):5450-4
2) Partaledis JA, et al.  (1992) Saccharomyces cerevisiae contains a homolog of human FKBP-13, a membrane-associated FK506/rapamycin binding protein. Yeast 8(8):673-80
3) Nielsen JB, et al.  (1992) Yeast FKBP-13 is a membrane-associated FK506-binding protein encoded by the nonessential gene FKB2. Proc Natl Acad Sci U S A 89(16):7471-5