FCP1/YMR277W Summary Help

Standard Name FCP1 1
Systematic Name YMR277W
Feature Type ORF, Verified
Description Carboxy-terminal domain (CTD) phosphatase; essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p); relocalizes to the cytosol in response to hypoxia (2, 3)
Name Description tfiiF-associating component of Ctd Phosphatase 1
Chromosomal Location
ChrXIII:820256 to 822454 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All FCP1 GO evidence and references
  View Computational GO annotations for FCP1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 6 genes
Resources
Classical genetics
overexpression
Large-scale survey
null
overexpression
reduction of function
Resources
85 total interaction(s) for 66 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 5
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 3
  • Biochemical Activity: 1
  • Co-crystal Structure: 2
  • Protein-peptide: 2
  • Reconstituted Complex: 4
  • Two-hybrid: 18

Genetic Interactions
  • Dosage Growth Defect: 3
  • Dosage Rescue: 8
  • Negative Genetic: 1
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 2
  • Positive Genetic: 5
  • Synthetic Growth Defect: 15
  • Synthetic Lethality: 13

Resources
Expression Summary
histogram
Resources
Length (a.a.) 732
Molecular Weight (Da) 83,440
Isoelectric Point (pI) 4.38
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:820256 to 822454 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2199 820256..822454 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004890
References cited on this page View Complete Literature Guide for FCP1
1) Archambault J, et al.  (1997) An essential component of a C-terminal domain phosphatase that interacts with transcription factor IIF in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 94(26):14300-5
2) Kops O, et al.  (2002) Pin1 modulates the dephosphorylation of the RNA polymerase II C-terminal domain by yeast Fcp1. FEBS Lett 513(2-3):305-11
3) Ghosh Dastidar R, et al.  (2012) The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation. Cell Biosci 2(1):30