Standard Name	FCJ1 1
Systematic Name	YKR016W
Alias	FMP13 2 , 3 , AIM28 4
Feature Type	ORF, Verified
Description	Mitochondrial inner membrane protein, ortholog of mammalian mitofilin; involved in import of intermembrane space (IMS) proteins, probably by positioning Mia40p relative to the TOM complex to receive incoming proteins; also has an essential role in the maintenance of crista junctions and inner membrane architecture, as a component of the mitochondrial inner membrane organizing system (MICOS, MitOS or MINOS), a scaffold-like structure on the IMS side of the inner membrane (1, 3, 5, 6, 7)
Name Description	Formation of Crista Junctions 1

Chromosomal Location	ChrXI:469717 to 471339 | ORF Map | GBrowse

	View Computational GO annotations for FCJ1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	cristae formation (IMP) protein import into mitochondrial intermembrane space (IMP, IPI)
Cellular Component
Manually curated	integral to mitochondrial inner membrane (IDA) mitochondrial crista (IDA) mitochondrial crista junction (IDA) mitochondrial inner membrane (IDA)
High-throughput	mitochondrion (IDA)

Classical genetics
null	mitochondrial morphology: abnormal mitochondrial transport: decreased mitophagy: absent Aim13p accumulation: absent Aim13p accumulation: decreased respiratory growth: decreased respiratory growth: absent respiratory metabolism: decreased viable
overexpression	mitochondrial morphology: abnormal
reduction of function	mitochondrial morphology: abnormal respiratory growth: absent respiratory growth: decreased
repressible	mitochondrial morphology: abnormal
Large-scale survey
null	competitive fitness: decreased mitochondrial genome maintenance: abnormal mitophagy: absent resistance to propan-1-ol: decreased resistance to methanol: decreased respiratory growth: decreased rate vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	398 total interaction(s) for 290 unique genes/features.
Physical Interactions	Affinity Capture-MS: 249 Affinity Capture-RNA: 3 Affinity Capture-Western: 39 Co-fractionation: 4 Co-purification: 20 Protein-peptide: 2 Two-hybrid: 2
Genetic Interactions	Negative Genetic: 71 Positive Genetic: 5 Synthetic Growth Defect: 1 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXI:469717 to 471339 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1623 469717..471339 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001724