MIC60/YKR016W Summary Help

Standard Name MIC60 1
Systematic Name YKR016W
Alias FMP13 2 , 3 , AIM28 4 , FCJ1 5
Feature Type ORF, Verified
Description Component of the MICOS complex; MICOS (formerly MINOS or MitOS) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane; Mic60p is also involved in import of intermembrane space (IMS) proteins, probably by positioning Mia40p relative to the TOM complex to receive incoming proteins; ortholog of mammalian mitofilin (3, 5, 6, 7, 8)
Name Description MItochondrial contact site and Cristae organizing system 1
Chromosomal Location
ChrXI:469717 to 471339 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All MIC60 GO evidence and references
  View Computational GO annotations for MIC60
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 1 genes
Resources
Classical genetics
null
overexpression
reduction of function
repressible
Large-scale survey
null
overexpression
Resources
396 total interaction(s) for 287 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 247
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 39
  • Co-fractionation: 4
  • Co-purification: 20
  • Protein-peptide: 2
  • Two-hybrid: 2

Genetic Interactions
  • Negative Genetic: 71
  • Positive Genetic: 5
  • Synthetic Growth Defect: 1
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 540
Molecular Weight (Da) 61,082
Isoelectric Point (pI) 6.54
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXI:469717 to 471339 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1623 469717..471339 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001724
References cited on this page View Complete Literature Guide for MIC60
1) Pfanner N, et al.  (2014) Uniform nomenclature for the mitochondrial contact site and cristae organizing system. J Cell Biol 204(7):1083-6
2) Meisinger, C., et al.  (2004) personal communication
3) Frederick RL, et al.  (2008) Multiple pathways influence mitochondrial inheritance in budding yeast. Genetics 178(2):825-37
4) Hess DC, et al.  (2009) Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis. PLoS Genet 5(3):e1000407
5) Rabl R, et al.  (2009) Formation of cristae and crista junctions in mitochondria depends on antagonism between Fcj1 and Su e/g. J Cell Biol 185(6):1047-63
6) von der Malsburg K, et al.  (2011) Dual role of mitofilin in mitochondrial membrane organization and protein biogenesis. Dev Cell 21(4):694-707
7) Hoppins S, et al.  (2011) A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria. J Cell Biol 195(2):323-40
8) Harner M, et al.  (2011) The mitochondrial contact site complex, a determinant of mitochondrial architecture.LID - 10.1038/emboj.2011.379 [doi] EMBO J ()