FAL1/YDR021W Summary

FAL1 BASIC INFORMATION

Standard Name	FAL1
Systematic Name	YDR021W
Feature Type	ORF, Verified
Description	Nucleolar protein required for maturation of 18S rRNA, member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases (1, 2)
Name Description	eukaryotic translation initiation factor Four A Like

GO Annotations	All FAL1 GO evidence and references
	View Computational GO annotations for FAL1
Molecular Function
Manually curated	ATP-dependent RNA helicase activity (TAS)
Biological Process
Manually curated	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) (IMP)
Cellular Component
Manually curated	nucleolus (TAS)

Mutant Phenotype	All FAL1 Phenotype details and references
Classical genetics
dominant negative	aberrant 23S rRNA processing intermediate accumulation: increased vegetative growth: decreased
null	inviable
Large-scale survey
null	inviable

Interactions	FAL1 All interactions details and references
	5 total interaction(s) for 5 unique genes/features.
Physical Interactions	Affinity Capture-MS: 3 Biochemical Activity: 1
Genetic Interactions	Synthetic Lethality: 1

Sequence Information

ChrIV:486802 to 488001 | |

Last Update

Coordinates: 2008-06-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1200	486802..488001	2008-06-05	1996-07-31

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000002428

FAL1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for FAL1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for FAL1]

1)	Wiederkehr T, et al. (1998) Synthetic lethal interactions with conditional poly(A) polymerase alleles identify LCP5, a gene involved in 18S rRNA maturation. RNA 4(11):1357-72
2)	Kressler D, et al. (1997) Fal1p is an essential DEAD-box protein involved in 40S-ribosomal-subunit biogenesis in Saccharomyces cerevisiae. Mol Cell Biol 17(12):7283-94

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