Search results for Locus Summary pages at SGD

Your query, F2, returned 88 hits to the following gene names:

Match Gene Name Systematic Name Alias(es) Position Info Description
ABF2 ABF2 YMR072W

ChrXIII:411569 to 412120 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..552 411569..412120

Mitochondrial DNA-binding protein; involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation; ABF2 has a paralog, IXR1, that arose from the whole genome duplication

ACF2 ACF2 YLR144C ENG2, PCA1

ChrXII:432016 to 429677 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..2340 432016..429677

Intracellular beta-1,3-endoglucanase; expression is induced during sporulation; may have a role in cortical actin cytoskeleton assembly; protein abundance increases in response to DNA replication stress

ARF2 ARF2 YDL137W Arf family GTPase ARF2

ChrIV:216529 to 217074 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
5' UTR intron -371..-40 216158..216489
CDS 1..546 216529..217074

Genetic position: -64 cM

ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; ARF2 has a paralog, ARF1, that arose from the whole genome duplication

ASF2 ASF2 YDL197C

ChrIV:106494 to 104917 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1578 106494..104917

Genetic position: -109.03 cM

Anti-silencing protein; causes derepression of silent loci when overexpressed

ATF2 ATF2 YGR177C

ChrVII:850436 to 848829 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1608 850436..848829

Alcohol acetyltransferase; may play a role in steroid detoxification; forms volatile esters during fermentation, which is important for brewing and winemaking

BDF2 BDF2 YDL070W

ChrIV:331024 to 332940 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1917 331024..332940

Protein involved in transcription initiation; acts at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf1p; protein abundance increases in response to DNA replication stress; BDF2 has a paralog, BDF1, that arose from the whole genome duplication

BUF2 RFA1 YAR007C BUF2, FUN3, RPA1, RPA70

ChrI:158619 to 156754 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1866 158619..156754

Genetic position: -3 cM

Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination; RPA protects against inappropriate telomere recombination, and upon telomere uncapping, prevents cell proliferation by a checkpoint-independent pathway; role in DNA catenation/decatenation pathway of chromosome disentangling; relocalizes to the cytosol in response to hypoxia

CAF20 CAF20 YOR276W CAF2, CAP20, p20

ChrXV:841333 to 841818 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..486 841333..841818

Phosphoprotein of the mRNA cap-binding complex; involved in translational control; repressor of cap-dependent translation initiation; competes with eIF4G for binding to eIF4E

CBF2 CBF2 YGR140W CBF3A, CEP2, CTF14, NDC10, CSL5

ChrVII:767429 to 770299 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..2871 767429..770299

Essential kinetochore protein; component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo; sumoylated in an Mms21p-dependent manner; relative distribution to the spindle pole body decreases upon DNA replication stress

CHF2 DMA2 YNL116W CHF2, ubiquitin-conjugating protein DMA2

ChrXIV:408341 to 409909 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1569 408341..409909

Ubiquitin-protein ligase (E3); controls septin dynamics and spindle position checkpoint (SPOC) with ligase Dma1p by regulating recruitment of Elm1p to bud neck; regulates levels of eIF2 subunit Gcd11p, as well as abundance, localization, and ubiquitination of Cdk inhibitory kinase Swe1p; ortholog of human RNF8, similar to human Chfr; contains FHA and RING finger domains; DMA2 has a paralog, DMA1, that arose from the whole genome duplication

DAF2 STE3 YKL178C DAF2

ChrXI:114627 to 113215 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1413 114627..113215

Receptor for a factor pheromone; couples to MAP kinase cascade to mediate pheromone response; transcribed in alpha cells and required for mating by alpha cells, ligand bound receptors endocytosed and recycled to the plasma membrane; GPCR

DBF2 DBF2 YGR092W serine/threonine-protein kinase DBF2

ChrVII:668189 to 669907 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1719 668189..669907

Genetic position: 28 cM

Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs; phosphorylates Chs2p to regulate primary septum formation and Hof1p to regulate cytokinesis; DBF2 has a paralog, DBF20, that arose from the whole genome duplication

DBF20 DBF20 YPR111W serine/threonine-protein kinase DBF20

ChrXVI:747306 to 749000 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1695 747306..749000

Genetic position: 66 cM

Ser/Thr kinase involved in late nuclear division; one of the mitotic exit network (MEN) proteins; necessary for the execution of cytokinesis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs; DBF20 has a paralog, DBF2, that arose from the whole genome duplication

DNF2 DNF2 YDR093W aminophospholipid-translocating P4-type ATPase DNF2

ChrIV:631282 to 636120 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..4839 631282..636120

Aminophospholipid translocase (flippase); localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase; DNF2 has a paralog, DNF1, that arose from the whole genome duplication

DSF2 DSF2 YBR007C

ChrII:251016 to 248806 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..2211 251016..248806

Deletion suppressor of mpt5 mutation; relocalizes from bud neck to cytoplasm upon DNA replication stress

EAF2 SWC4 YGR002C EAF2, GOD1

ChrVII:499906 to 498476 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1431 499906..498476

Component of the Swr1p complex that incorporates Htz1p into chromatin; component of the NuA4 histone acetyltransferase complex

ERF2 ERF2 YLR246W

ChrXII:627118 to 628197 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1080 627118..628197

Subunit of a palmitoyltransferase; this complex adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; mutants partially mislocalize Ras2p to the vacuole; palmitoyltransferase is composed of Erf2p and Shr5p

ESF2 ESF2 YNR054C ABT1

ChrXIV:724306 to 723356 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..951 724306..723356

Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit (SSU) processome

FCF2 FCF2 YLR051C

ChrXII:246977 to 246324 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..654 246977..246324

Nucleolar protein involved in the early steps of 35S rRNA processing; interacts with Faf1p; member of a transcriptionally co-regulated set of genes called the RRB regulon; essential gene

GEF2 VMA3 YEL027W CLS7, GEF2, CUP5, H(+)-transporting V0 sector ATPase subunit c

ChrV:100769 to 101251 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..483 100769..101251

Genetic position: -18 cM

Proteolipid subunit c of the V0 domain of vacuolar H(+)-ATPase; dicyclohexylcarbodiimide binding subunit; required for vacuolar acidification and important for copper and iron metal ion homeostasis

GRF2 REB1 YBR049C GRF2

ChrII:336818 to 334386 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..2433 336818..334386

RNA polymerase I enhancer binding protein; DNA binding protein that binds to genes transcribed by both RNA polymerase I and RNA polymerase II; required for termination of RNA polymerase I transcription; REB1 has a paralog, NSI1, that arose from the whole genome duplication

GSF2 GSF2 YML048W ECM6

ChrXIII:178426 to 179637 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1212 178426..179637

Endoplasmic reticulum (ER) localized integral membrane protein; may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression

HAF2 SWI3 YJL176C TYE2, HAF2

ChrX:94530 to 92053 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..2478 94530..92053

Subunit of the SWI/SNF chromatin remodeling complex; SWI/SNF regulates transcription by remodeling chromosomes; contains SANT domain that is required for SWI/SNF assembly; is essential for displacement of histone H2A-H2B dimers during ATP-dependent remodeling; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; relocates to the cytosol under hypoxic conditions

HDF2 YKU80 YMR106C HDF2

ChrXIII:480190 to 478301 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1890 480190..478301

Subunit of the telomeric Ku complex (Yku70p-Yku80p); involved in telomere length maintenance, structure and telomere position effect; required for localization of telomerase ribonucleoprotein via interaction with the TLC1 guide RNA; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair

HHF2 HHF2 YNL030W histone H4

ChrXIV:576727 to 577038 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..312 576727..577038

Histone H4; core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF1); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity

HPF2 PST1 YDR055W HPF2

ChrIV:563527 to 564861 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1335 563527..564861

Cell wall protein that contains a putative GPI-attachment site; secreted by regenerating protoplasts; up-regulated by activation of the cell integrity pathway, as mediated by Rlm1p; upregulated by cell wall damage via disruption of FKS1; PST1 has a paralog, ECM33, that arose from the whole genome duplication

HUF2 FLC2 YAL053W HUF2

ChrI:45899 to 48250 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..2352 45899..48250

Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC2 has a paralog, YOR365C, that arose from the whole genome duplication

LIF2 NEJ1 YLR265C LIF2

ChrXII:675455 to 674427 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1029 675455..674427

Protein involved in regulation of nonhomologous end joining; interacts with DNA ligase IV components Dnl4p and Lif1p; repressed by MAT heterozygosity; regulates cellular distribution of Lif1p

LPF2 BRO1 YPL084W LPF2, VPS31, ASI6, NPI3

ChrXVI:394038 to 396572 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..2535 394038..396572

Cytoplasmic class E vacuolar protein sorting (VPS) factor; coordinates deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes

MEF2 MEF2 YJL102W

ChrX:231301 to 233760 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..2460 231301..233760

Mitochondrial elongation factor involved in translational elongation

MHF2 MHF2 YDL160C-A

ChrIV:169608 to 169366 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..243 169608..169366

Component of the heterotetrameric MHF histone-fold complex; in humans the MMF complex interacts with both DNA and Mph1p ortholog FANCM to stabilize and remodel blocked replication forks and repair damaged DNA; mhf2 srs2 double mutants are MMS hypersensitive; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-X, also known as MHF2

MIF2 MAS2 YHR024C MIF2, mitochondrial processing protease alpha subunit

ChrVIII:159192 to 157744 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1449 159192..157744

Genetic position: 26 cM

Larger subunit of the mitochondrial processing protease (MPP); essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins

MIF2 MIF2 YKL089W

ChrXI:273394 to 275043 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1650 273394..275043

Genetic position: -43 cM

Protein required for structural integrity of elongating spindles; localizes to the kinetochore; interacts with histones H2A, H2B, and H4; phosphorylated by Ipl1p; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-C and fission yeast cnp3

MOF2 SUI1 YNL244C MOF2, RFR1, translation initiation factor eIF1

ChrXIV:187496 to 187170 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..327 187496..187170

Genetic position: -171 cM

Translation initiation factor eIF1; component of a complex involved in recognition of the initiator codon; modulates translation accuracy at the initiation phase

MTF2 MTF2 YDL044C NAM1

ChrIV:375289 to 373967 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1323 375289..373967

Genetic position: -17.93 cM

Mitochondrial protein that interacts with mitochondrial RNA polymerase; interacts with an N-terminal region of mitochondrial RNA polymerase (Rpo41p) and couples RNA processing and translation to transcription

NNF2 NNF2 YGR089W

ChrVII:656960 to 659770 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..2811 656960..659770

Protein that exhibits physical and genetic interactions with Rpb8p; Rpb8p is a subunit of RNA polymerases I, II, and III; computational analysis of large-scale protein-protein interaction data suggests a role in chromosome segregation

NTF2 NTF2 YER009W

ChrV:172115 to 172492 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..378 172115..172492

Nuclear envelope protein; interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport

NUF2 NUF2 YOL069W

ChrXV:198942 to 200297 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1356 198942..200297

Component of the kinetochore-associated Ndc80 complex; involved in chromosome segregation, spindle checkpoint activity, and kinetochore clustering; evolutionarily conserved; other members include Ndc80p, Nuf2p, Spc24p, and Spc25p

OAF2 PIP2 YOR363C OAF2

ChrXV:1023212 to 1020222 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..2991 1023212..1020222

Oleate-specific transcriptional activator of peroxisome proliferation; autoregulatory; contains Zn(2)-Cys(6) cluster domain, forms heterodimer with Oaf1p, binds oleate response elements (OREs), activates beta-oxidation genes; PIP2 has a paralog, OAF1, that arose from the whole genome duplication

PBF2 DOT6 YER088C PBF2

ChrV:335188 to 333176 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..2013 335188..333176

Protein involved in rRNA and ribosome biogenesis; binds polymerase A and C motif; subunit of the RPD3L histone deacetylase complex; has chromatin specific SANT domain; involved in telomeric gene silencing and filamentation; DOT6 has a paralog, TOD6, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress

PPF2 PEA2 YER149C DFG9, PPF2

ChrV:467470 to 466208 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1263 467470..466208

Coiled-coil 12S polarisome subunit; required for polarity establishment, apical bud growth, shmoo formation during mating, and filamentous differentiation; involved in the localization of Bni1p at sites of polarized growth, thereby controlling the polarized assembly of actin cables; role in apical growth affects diploid-specific bipolar bud site selection; retains Slt2p at the bud tip to regulate ER inheritance; role in low affinity Ca2+ influx and cell fusion during mating

PSF2 PSF2 YJL072C CDC102

ChrX:305862 to 305221 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..642 305862..305221

Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p); complex is localized to DNA replication origins and implicated in assembly of the DNA replication machinery

PUF2 PUF2 YPR042C

ChrXVI:653662 to 650435 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..3228 653662..650435

PUF family mRNA-binding protein; Pumilio homology domain confers RNA binding activity; preferentially binds mRNAs encoding membrane-associated proteins; binding site composed of two UAAU tetranucleotides, separated by a 3-nt linker; PUF2 has a paralog, JSN1, that arose from the whole genome duplication

PZF240 REG1 YDR028C HEX2, PZF240, SPP43, SRN1

ChrIV:500879 to 497835 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..3045 500879..497835

Genetic position: 2.79 cM

Regulatory subunit of type 1 protein phosphatase Glc7p; involved in negative regulation of glucose-repressible genes; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; REG1 has a paralog, REG2, that arose from the whole genome duplication

RBF20 TMA20 YER007C-A RBF20

ChrV:166885 to 166237 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..11 166885..166875
Intron 12..114 166874..166772
CDS 115..649 166771..166237

Protein of unknown function that associates with ribosomes; has a putative RNA binding domain; interacts with Tma22p; null mutant exhibits translation defects; has homology to human oncogene MCT-1; protein abundance increases in response to DNA replication stress

RBF22 TMA22 YJR014W RBF22

ChrX:461829 to 462425 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..597 461829..462425

Protein of unknown function; associates with ribosomes and has a putative RNA binding domain; interacts with Tma20p; similar to human GRAP and human DRP1, which interacts with human Tma20p homolog MCT-1; protein abundance increases in response to DNA replication stress

RCF2 RCF2 YNR018W AIM38

ChrXIV:664270 to 664944 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..675 664270..664944

Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast

REF2 REF2 YDR195W

ChrIV:848599 to 850200 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1602 848599..850200

RNA-binding protein; involved in the cleavage step of mRNA 3'-end formation prior to polyadenylation, and in snoRNA maturation; part of holo-CPF subcomplex APT, which associates with 3'-ends of snoRNA- and mRNA-encoding genes; relocalizes to the cytosol in response to hypoxia

RF2 RF2 RF2

ChrMito

Maturase-like coding sequence downstream of COX3/Q0275; present in some S. cerevisiae strains and other Saccharomyces species; compound ORF with homology to other group I open reading frames; in S288C is interrupted by two GC clusters, both of which ultimately result in a -1 frameshlft

RIF2 RIF2 YLR453C

ChrXII:1042986 to 1041799 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1188 1042986..1041799

Protein that binds to the Rap1p C-terminus; acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation; RIF2 has a paralog, ORC4, that arose from the whole genome duplication

RLF2 RLF2 YPR018W CAC1

ChrXVI:594476 to 596296 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1821 594476..596296

Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1); chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; chromatin dynamics during transcription; and repression of divergent noncoding transcription

RPF2 RPF2 YKR081C

ChrXI:592540 to 591506 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1035 592540..591506

Essential protein involved in rRNA maturation and ribosomal assembly; involved in the processing of pre-rRNA and the assembly of the 60S ribosomal subunit; interacts with ribosomal protein L11; localizes predominantly to the nucleolus; constituent of 66S pre-ribosomal particles

RSF2 RSF2 YJR127C ZMS1

ChrX:663059 to 658917 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..4143 663059..658917

Zinc-finger protein; involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions; RSF2 has a paralog, TDA9, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasm upon DNA replication stress

RUF2 SNR82 snR82 RUF2

ChrVII:316788 to 317055 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
Noncoding exon 1..268 316788..317055

H/ACA box small nucleolar RNA (snoRNA); guides pseudouridylation of large subunit (LSU) rRNA at positions U1110, U2349, and U2351

RUF20 RUF20 RUF20

ChrVI:131503 to 131061 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
Noncoding exon 1..443 131503..131061

RNA of Unknown Function

RUF21 RUF21 RUF21

ChrVI:58521 to 57815 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
Noncoding exon 1..707 58521..57815

RNA of Unknown Function

RUF22 RUF22 RUF22

ChrVI:199813 to 199299 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
Noncoding exon 1..515 199813..199299

RNA of Unknown Function; precise location of 3' end uncertain; RUF22 may be longer than currently annotated

RUF23 RUF23 RUF23

ChrVI:221714 to 221967 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
Noncoding exon 1..254 221714..221967

RNA of Unknown Function; precise location of 3' end uncertain; RUF23 may be longer than currently annotated

SGF29 SGF29 YCL010C

ChrIII:104350 to 103571 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..780 104350..103571

Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes; HAT/Core module also contains Gcn5p, Ngg1p, and Ada2p; binds methylated histone H3K4; involved in transcriptional regulation through SAGA and TBP recruitment to target promoters and H3 acetylation

SIF2 SIF2 YBR103W EMB1

ChrII:447709 to 449316 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1608 447709..449316

WD40 repeat-containing subunit of Set3C histone deacetylase complex; complex represses early/middle sporulation genes; antagonizes telomeric silencing; binds specifically to the Sir4p N-terminus

SMF2 SMF2 YHR050W divalent metal ion transporter SMF2

ChrVIII:207654 to 209303 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1650 207654..209303

Divalent metal ion transporter involved in manganese homeostasis; has broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins

SNF2 SNF2 YOR290C GAM1, HAF1, SWI2, TYE3

ChrXV:860258 to 855147 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..5112 860258..855147

Catalytic subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p

SRF2 YJR114W SRF2

ChrX:638659 to 639051 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..393 638659..639051

Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSM7/YJR113C

SSF2 SSF2 YDR312W

ChrIV:1087581 to 1088942 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1362 1087581..1088942

Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication

STF2 STF2 YGR008C

ChrVII:508364 to 508110 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..255 508364..508110

Protein involved in resistance to desiccation stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to F0 sector of mitochondrial F1F0 ATPase in vitro and may modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress; STF2 has a paralog, TMA10, that arose from the whole genome duplication

SUF2 SUF2 tP(AGG)C

ChrIII:123648 to 123577 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
Noncoding exon 1..72 123648..123577

Genetic position: 2 cM

Proline tRNA (tRNA-Pro), predicted by tRNAscan-SE analysis; can mutate to suppress +1 frameshift mutations in proline codons

SUF20 SUF20 tG(GCC)F1

ChrVI:162228 to 162298 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
Noncoding exon 1..71 162228..162298

Genetic position: 6 cM

Glycine tRNA (tRNA-Gly), predicted by tRNAscan-SE analysis; can mutate to suppress +1 frameshift mutations in glycine codons

SUF21 SUF21 SUF21

ChrXVI

Genetic position: 3 cM

SUF22 SUF22 SUF22

ChrXIII

Genetic position: -31 cM

SUF23 SUF23 tG(GCC)J2

ChrX:531828 to 531898 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
Noncoding exon 1..71 531828..531898

Glycine tRNA (tRNA-Gly); can mutate to suppress +1 frameshift mutations

SUF24 SUF24 SUF24

ChrIV

Genetic position: 160 cM

SUF25 SUF25 SUF25

ChrIV

Genetic position: -115 cM

SYF2 SYF2 YGR129W NTC31

ChrVII:750400 to 751047 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..648 750400..751047

Member of the NineTeen Complex (NTC); NTC contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; relocalizes to the cytosol in response to hypoxia; isy1 syf2 cells have defective spindles activiating cell cycle arrest

TAF2 TAF2 YCR042C TAF150, TSM1, TafII150

ChrIII:205397 to 201174 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..4224 205397..201174

Genetic position: 31 cM

TFIID subunit (150 kDa); involved in RNA polymerase II transcription initiation

TAF23
TAF25
TAF10 YDR167W TAF23, TAF25, TafII25

ChrIV:789449 to 790069 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..621 789449..790069

Subunit (145 kDa) of TFIID and SAGA complexes; involved in RNA polymerase II transcription initiation and in chromatin modification

TEF2 TEF2 YBR118W EF-1 alpha, eEF1A, translation elongation factor EF-1 alpha

ChrII:477671 to 479047 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1377 477671..479047

Genetic position: 61 cM

Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; TEF2-RFP levels increase during replicative aging; may also have a role in tRNA re-export from the nucleus; TEF2 has a paralog, TEF1, that arose from the whole genome duplication

tG(GCC)F2 tG(GCC)F2

ChrVI:181044 to 180974 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
Noncoding exon 1..71 181044..180974

Glycine tRNA (tRNA-Gly), predicted by tRNAscan-SE analysis

TIF2 TIF2 YJL138C eIF4A, translation initiation factor eIF4A

ChrX:154691 to 153504 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1188 154691..153504

Genetic position: -92 cM

Translation initiation factor eIF4A; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G; protein abundance increases in response to DNA replication stress; TIF2 has a paralog, TIF1, that arose from the whole genome duplication

TOF2 TOF2 YKR010C

ChrXI:461239 to 458924 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..2316 461239..458924

Protein required for rDNA silencing and mitotic rDNA condensation; stimulates Cdc14p phosphatase activity and biphasic release to promote rDNA repeat segregation; required for condensin recruitment to the replication fork barrier site; TOF2 has a paralog, NET1, that arose from the whole genome duplication

translation initiation factor eIF2 subunit alpha SUI2 YJR007W translation initiation factor eIF2 subunit alpha

ChrX:451020 to 451934 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..915 451020..451934

Genetic position: 2 cM

Alpha subunit of the translation initiation factor eIF2; eIF2 is involved in identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP; protein abundance increases in response to DNA replication stress

translation initiation factor eIF2 subunit beta SUI3 YPL237W translation initiation factor eIF2 subunit beta

ChrXVI:100496 to 101353 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..858 100496..101353

Beta subunit of the translation initiation factor eIF2; involved in the identification of the start codon; proposed to be involved in mRNA binding

translation initiation factor eIF2 subunit gamma GCD11 YER025W SUI4, translation initiation factor eIF2 subunit gamma

ChrV:205251 to 206834 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1584 205251..206834

Genetic position: 14 cM

Gamma subunit of the translation initiation factor eIF2; involved in the identification of the start codon; binds GTP when forming the ternary complex with GTP and tRNAi-Met; mutations in human ortholog cause X-linked intellectual disability (XLID)

translation initiation factor eIF2B subunit alpha GCN3 YKR026C AAS2, translation initiation factor eIF2B subunit alpha

ChrXI:489655 to 488738 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..918 489655..488738

Genetic position: 7 cM

Alpha subunit of translation initiation factor eIF2B; guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; positive regulator of GCN4 expression; assembles into filaments with Gcd2p, Gcd6p, Gcd7p, and Sui2p as cells approach stationary phase and under cytosolic acidification and starvation conditions

translation initiation factor eIF2B subunit beta GCD7 YLR291C translation initiation factor eIF2B subunit beta

ChrXII:719462 to 718317 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1146 719462..718317

Beta subunit of the translation initiation factor eIF2B; the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression

tY(GUA)F2 SUP6 tY(GUA)F2

ChrVI:210707 to 210619 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
Noncoding exon 1..39 210707..210669
Intron 40..53 210668..210655
Noncoding exon 54..89 210654..210619

Genetic position: 38 cM

Tyrosine tRNA (tRNA-Tyr), predicted by tRNAscan-SE analysis; can mutate to suppress ochre nonsense mutations

UPF2 NMD2 YHR077C IFS1, SUA1, UPF2, SUP111

ChrVIII:255756 to 252374 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..6 255756..255751
Intron 7..119 255750..255638
CDS 120..3383 255637..252374

Genetic position: 51 cM

Protein involved in the nonsense-mediated mRNA decay (NMD) pathway; interacts with Nam7p and Upf3p; involved in telomere maintenance

yIF2 FUN12 YAL035W yIF2, eIF5B, translation initiation factor eIF5B

ChrI:76427 to 79435 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..3009 76427..79435

Translation initiation factor eIF5B; GTPase that promotes Met-tRNAiMet binding to ribosomes and ribosomal subunit joining; promotes GTP-dependent maturation of 18S rRNA by Nob1p; protein abundance increases in response to DNA replication stress; homolog of bacterial IF2

YLF2 YLF2 YHL014C YLF1

ChrVIII:77314 to 76097 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1218 77314..76097

Protein of unknown function; has weak similarity to E. coli GTP-binding protein gtp1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies