EXO5/YBR163W Summary Help

Standard Name EXO5 1, 2
Systematic Name YBR163W
Alias DEM1 3
Feature Type ORF, Verified
Description Mitochondrial 5'-3' exonuclease and sliding exonuclease; required for mitochondrial genome maintenance; distantly related to the RecB nuclease domain of bacterial RecBCD recombinases; may be regulated by the transcription factor Ace2 (2, 3, 4, 5)
Name Description EXOnuclease V 2
Chromosomal Location
ChrII:565723 to 567480 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All EXO5 GO evidence and references
  View Computational GO annotations for EXO5
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 6 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
13 total interaction(s) for 13 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 9
  • Affinity Capture-RNA: 1

Genetic Interactions
  • Negative Genetic: 1
  • Synthetic Haploinsufficiency: 1
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 585
Molecular Weight (Da) 67,569
Isoelectric Point (pI) 7.24
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrII:565723 to 567480 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1758 565723..567480 2011-02-03 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000367
References cited on this page View Complete Literature Guide for EXO5
1) Burgers PM, et al.  (1988) Exonuclease V from Saccharomyces cerevisiae. A 5'----3'-deoxyribonuclease that produces dinucleotides in a sequential fashion. J Biol Chem 263(17):8099-105
2) Burgers PM, et al.  (2010) Yeast exonuclease 5 is essential for mitochondrial genome maintenance. Mol Cell Biol 30(6):1457-66
3) Entian KD, et al.  (1999) Functional analysis of 150 deletion mutants in Saccharomyces cerevisiae by a systematic approach. Mol Gen Genet 262(4-5):683-702
4) Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
5) Sun W, et al.  (2007) Detection of eQTL modules mediated by activity levels of transcription factors. Bioinformatics 23(17):2290-7