Standard Name	ESC2 1
Systematic Name	YDR363W
Feature Type	ORF, Verified
Description	Sumo-like domain protein; prevents accumulation of toxic intermediates during replication-associated recombinational repair; roles in silencing, lifespan, chromatid cohesion and the intra-S-phase DNA damage checkpoint; RENi family member (1, 2, 3, 4, 5)
Name Description	Establishment of Silent Chromatin 1

Chromosomal Location	ChrIV:1199183 to 1200553 | ORF Map | GBrowse

	View Computational GO annotations for ESC2
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	chromatin silencing at silent mating-type cassette (IMP) double-strand break repair via homologous recombination (IGI, IMP) intra-S DNA damage checkpoint (IGI, IMP) mitotic sister chromatid cohesion (IGI, IMP)
Cellular Component
Manually curated	nucleus (IDA)

Classical genetics
null	chromosome/plasmid maintenance: abnormal mitotic recombination: increased rate GFP-Rad52p distribution: increased replicative lifespan: decreased resistance to hydroxyurea: decreased resistance to methyl methanesulfonate: decreased resistance to sirolimus: increased silencing: decreased viable
Large-scale survey
null	auxotrophy budding index: increased competitive fitness: decreased dessication resistance: decreased heat sensitivity: increased mitotic recombination: increased Rad52-YFP distribution: increased resistance to camptothecin: increased resistance to cycloheximide: increased resistance to fluconazole: increased resistance to caffeine: decreased resistance to methyl methanesulfonate: decreased resistance to tenovin-6: decreased resistance to doxorubicin: decreased stress resistance: decreased transposable element transposition: increased vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	210 total interaction(s) for 112 unique genes/features.
Physical Interactions	Affinity Capture-MS: 1 Affinity Capture-Western: 4 Two-hybrid: 6
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 92 Phenotypic Enhancement: 5 Phenotypic Suppression: 1 Positive Genetic: 7 Synthetic Growth Defect: 57 Synthetic Lethality: 33 Synthetic Rescue: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:1199183 to 1200553 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1371 1199183..1200553 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002771