ESC2/YDR363W Summary Help

Standard Name ESC2 1
Systematic Name YDR363W
Feature Type ORF, Verified
Description Sumo-like domain protein; prevents accumulation of toxic intermediates during replication-associated recombinational repair; roles in silencing, lifespan, chromatid cohesion and the intra-S-phase DNA damage checkpoint; RENi family member (1, 2, 3, 4, 5)
Name Description Establishment of Silent Chromatin 1
Chromosomal Location
ChrIV:1199183 to 1200553 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All ESC2 GO evidence and references
  View Computational GO annotations for ESC2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Classical genetics
null
Large-scale survey
null
Resources
214 total interaction(s) for 112 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-Western: 4
  • Two-hybrid: 6

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 91
  • Phenotypic Enhancement: 5
  • Phenotypic Suppression: 3
  • Positive Genetic: 7
  • Synthetic Growth Defect: 59
  • Synthetic Lethality: 33
  • Synthetic Rescue: 4

Resources
Expression Summary
histogram
Resources
Length (a.a.) 456
Molecular Weight (Da) 52,541
Isoelectric Point (pI) 4.79
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:1199183 to 1200553 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1371 1199183..1200553 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002771
References cited on this page View Complete Literature Guide for ESC2
1) Dhillon N and Kamakaka RT  (2000) A histone variant, Htz1p, and a Sir1p-like protein, Esc2p, mediate silencing at HMR. Mol Cell 6(4):769-80
2) Novatchkova M, et al.  (2005) Proteins with two SUMO-like domains in chromatin-associated complexes: the RENi (Rad60-Esc2-NIP45) family. BMC Bioinformatics 6():22
3) Ohya T, et al.  (2008) A SUMO-Like Domain Protein, Esc2, Is Required for Genome Integrity and Sister Chromatid Cohesion in Saccharomyces cerevisiae. Genetics 180(1):41-50
4) Mankouri HW, et al.  (2009) Esc2 and Sgs1 act in functionally distinct branches of the homologous recombination repair pathway in Saccharomyces cerevisiae. Mol Biol Cell 20(6):1683-94
5) Choi K, et al.  (2010) The Smc5/6 complex and Esc2 influence multiple replication-associated recombination processes in Saccharomyces cerevisiae. Mol Biol Cell 21(13):2306-14