ESC1/YMR219W Summary Help

Standard Name ESC1 1
Systematic Name YMR219W
Feature Type ORF, Verified
Description Protein localized to the nuclear periphery; involved in telomeric silencing; interacts with PAD4-domain of Sir4p (1)
Name Description Establishes Silent Chromatin 1
Chromosomal Location
ChrXIII:707133 to 712109 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All ESC1 GO evidence and references
  View Computational GO annotations for ESC1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 1 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Resources
101 total interaction(s) for 69 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 6
  • Affinity Capture-RNA: 2
  • Co-purification: 1
  • Two-hybrid: 8

Genetic Interactions
  • Negative Genetic: 64
  • Phenotypic Enhancement: 7
  • Phenotypic Suppression: 2
  • Positive Genetic: 2
  • Synthetic Growth Defect: 7
  • Synthetic Lethality: 1
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 1,658
Molecular Weight (Da) 187,136
Isoelectric Point (pI) 4.22
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:707133 to 712109 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..4977 707133..712109 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004832
References cited on this page View Complete Literature Guide for ESC1
1) Andrulis ED, et al.  (2002) Esc1, a nuclear periphery protein required for Sir4-based plasmid anchoring and partitioning. Mol Cell Biol 22(23):8292-301