ESC1/YMR219W Summary

ESC1 BASIC INFORMATION

Standard Name	ESC1 1
Systematic Name	YMR219W
Feature Type	ORF, Verified
Description	Protein localized to the nuclear periphery, involved in telomeric silencing; interacts with PAD4-domain of Sir4p (1)
Name Description	Establishes Silent Chromatin 1

GO Annotations	All ESC1 GO evidence and references
	View Computational GO annotations for ESC1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	chromatin silencing at telomere (IMP)
Cellular Component
Manually curated	nuclear periphery (IDA)

Mutant Phenotype	All ESC1 Phenotype details and references
Classical genetics
overexpression	nuclear morphology: abnormal
Large-scale survey
null	competitive fitness: decreased fermentative growth: decreased rate resistance to arsenite(3-): decreased transposable element transposition: increased viable

Interactions	ESC1 All interactions details and references
	View additional details at BioGRID
	89 total interaction(s) for 61 unique genes/features.
Physical Interactions	Affinity Capture-MS: 6 Affinity Capture-RNA: 1 Two-hybrid: 6
Genetic Interactions	Negative Genetic: 63 Phenotypic Enhancement: 4 Phenotypic Suppression: 1 Positive Genetic: 2 Synthetic Growth Defect: 4 Synthetic Lethality: 1 Synthetic Rescue: 1

Sequence Information

ChrXIII:707132 to 712108 | |

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..4977	707132..712108	1996-07-31	1996-07-31

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000004832

ESC1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for ESC1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for ESC1]

1)	Andrulis ED, et al. (2002) Esc1, a nuclear periphery protein required for Sir4-based plasmid anchoring and partitioning. Mol Cell Biol 22(23):8292-301

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