Standard Name	ESC1 1
Systematic Name	YMR219W
Feature Type	ORF, Verified
Description	Protein localized to the nuclear periphery, involved in telomeric silencing; interacts with PAD4-domain of Sir4p (1)
Name Description	Establishes Silent Chromatin 1

Chromosomal Location	ChrXIII:707133 to 712109 | ORF Map | GBrowse

	View Computational GO annotations for ESC1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	chromatin silencing at telomere (IMP)
Cellular Component
Manually curated	nuclear periphery (IDA)

Classical genetics
null	chromosome/plasmid maintenance: abnormal
overexpression	nuclear morphology: abnormal
Large-scale survey
null	competitive fitness: decreased fermentative growth: decreased rate haploproficient resistance to arsenite(3-): decreased resistance to camptothecin: decreased resistance to caffeine: decreased resistance to fluconazole: decreased resistance to bleomycin: decreased transposable element transposition: increased viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	100 total interaction(s) for 68 unique genes/features.
Physical Interactions	Affinity Capture-MS: 6 Affinity Capture-RNA: 2 Two-hybrid: 8
Genetic Interactions	Negative Genetic: 64 Phenotypic Enhancement: 7 Phenotypic Suppression: 2 Positive Genetic: 2 Synthetic Growth Defect: 7 Synthetic Lethality: 1 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIII:707133 to 712109 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..4977 707133..712109 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004832