ESA1/YOR244W Summary Help

Standard Name ESA1 1
Systematic Name YOR244W
Alias TAS1
Feature Type ORF, Verified
Description Catalytic subunit of the histone acetyltransferase complex (NuA4); acetylates four conserved internal lysines of histone H4 N-terminal tail and can acetylate histone H2A; master regulator of cellular acetylation balance; required for cell cycle progression and transcriptional silencing at the rDNA locus and regulation of autophagy; human ortholog TIP60/KAT5 is implicated in cancer and other diseases (1, 2, 3, 4, 5, 6)
Gene Product Alias KAT5 7
Chromosomal Location
ChrXV:792531 to 793868 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All ESA1 GO evidence and references
  View Computational GO annotations for ESA1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 2 genes
Resources
Classical genetics
conditional
reduction of function
unspecified
Large-scale survey
conditional
null
overexpression
reduction of function
repressible
Resources
949 total interaction(s) for 631 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 170
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 38
  • Biochemical Activity: 110
  • Co-crystal Structure: 1
  • Co-localization: 2
  • Co-purification: 13
  • Reconstituted Complex: 4
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Rescue: 8
  • Negative Genetic: 66
  • Phenotypic Enhancement: 3
  • Phenotypic Suppression: 8
  • Positive Genetic: 6
  • Synthetic Growth Defect: 338
  • Synthetic Lethality: 162
  • Synthetic Rescue: 17

Resources
Expression Summary
histogram
Resources
Length (a.a.) 445
Molecular Weight (Da) 52,612
Isoelectric Point (pI) 7.72
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:792531 to 793868 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1338 792531..793868 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005770
References cited on this page View Complete Literature Guide for ESA1
1) Clarke AS, et al.  (1999) Esa1p is an essential histone acetyltransferase required for cell cycle progression. Mol Cell Biol 19(4):2515-26
2) Allard S, et al.  (1999) NuA4, an essential transcription adaptor/histone H4 acetyltransferase complex containing Esa1p and the ATM-related cofactor Tra1p. EMBO J 18(18):5108-19
3) Smith ER, et al.  (1998) ESA1 is a histone acetyltransferase that is essential for growth in yeast. Proc Natl Acad Sci U S A 95(7):3561-5
4) Clarke AS, et al.  (2006) Distinct roles for the essential MYST family HAT Esa1p in transcriptional silencing. Mol Biol Cell 17(4):1744-57
5) Yi C, et al.  (2012) Function and molecular mechanism of acetylation in autophagy regulation. Science 336(6080):474-7
6) Torres-Machorro AL and Pillus L  (2014) Bypassing the Requirement for an Essential MYST Acetyltransferase. Genetics ()
7) Allis CD, et al.  (2007) New nomenclature for chromatin-modifying enzymes. Cell 131(4):633-6