ERV29/YGR284C Summary Help

Standard Name ERV29
Systematic Name YGR284C
Feature Type ORF, Verified
Description Protein localized to COPII-coated vesicles; involved in vesicle formation and incorporation of specific secretory cargo; protein abundance increases in response to DNA replication stress (1, 2, 3)
Name Description ER Vesicle
Chromosomal Location
ChrVII:1061590 to 1060658 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All ERV29 GO evidence and references
  View Computational GO annotations for ERV29
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 9 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Resources
149 total interaction(s) for 115 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 17
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 1
  • Co-fractionation: 1
  • Co-purification: 1
  • PCA: 59
  • Protein-RNA: 1
  • Two-hybrid: 2

Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 1
  • Negative Genetic: 25
  • Phenotypic Enhancement: 6
  • Phenotypic Suppression: 17
  • Positive Genetic: 10
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 2
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 310
Molecular Weight (Da) 35,013
Isoelectric Point (pI) 10.47
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:1061590 to 1060658 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..933 1061590..1060658 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003516
References cited on this page View Complete Literature Guide for ERV29
1) Caldwell SR, et al.  (2001) Degradation of endoplasmic reticulum (ER) quality control substrates requires transport between the ER and Golgi. J Biol Chem 276(26):23296-303
2) Belden WJ and Barlowe C  (2001) Role of Erv29p in collecting soluble secretory proteins into ER-derived transport vesicles. Science 294(5546):1528-31
3) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76