ERV25/YML012W Summary Help

Standard Name ERV25
Systematic Name YML012W
Feature Type ORF, Verified
Description Member of the p24 family involved in ER to Golgi transport; role in misfolded protein quality control; forms a heterotrimeric complex with Erp1, Erp2p, and Emp24, (1, 2, 3, 4)
Name Description ER Vesicle
Chromosomal Location
ChrXIII:246116 to 246751 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All ERV25 GO evidence and references
  View Computational GO annotations for ERV25
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 7 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
297 total interaction(s) for 162 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 42
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 11
  • Biochemical Activity: 1
  • Co-fractionation: 2
  • Co-purification: 3
  • PCA: 51
  • Protein-peptide: 5
  • Reconstituted Complex: 4

Genetic Interactions
  • Negative Genetic: 101
  • Phenotypic Enhancement: 15
  • Phenotypic Suppression: 36
  • Positive Genetic: 17
  • Synthetic Growth Defect: 4
  • Synthetic Lethality: 2
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 211
Molecular Weight (Da) 24,106
Isoelectric Point (pI) 5.26
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:246116 to 246751 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..636 246116..246751 1996-07-31 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004473
References cited on this page View Complete Literature Guide for ERV25
1) Belden WJ and Barlowe C  (1996) Erv25p, a component of COPII-coated vesicles, forms a complex with Emp24p that is required for efficient endoplasmic reticulum to Golgi transport. J Biol Chem 271(43):26939-46
2) Muniz M, et al.  (2000) The Emp24 complex recruits a specific cargo molecule into endoplasmic reticulum-derived vesicles. J Cell Biol 148(5):925-30
3) Marzioch M, et al.  (1999) Erp1p and Erp2p, partners for Emp24p and Erv25p in a yeast p24 complex. Mol Biol Cell 10(6):1923-38
4) Copic A, et al.  (2009) Genomewide analysis reveals novel pathways affecting endoplasmic reticulum homeostasis, protein modification and quality control. Genetics 182(3):757-69