ERV2/YPR037C Summary Help

Standard Name ERV2 1
Systematic Name YPR037C
Feature Type ORF, Verified
Description Flavin-linked sulfhydryl oxidase localized to the ER lumen; involved in disulfide bond formation within the endoplasmic reticulum (ER) (2, 3)
Name Description Essential for Respiration and Viability 4
Chromosomal Location
ChrXVI:647038 to 646448 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All ERV2 GO evidence and references
  View Computational GO annotations for ERV2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 3 genes
Resources
Large-scale survey
null
Resources
20 total interaction(s) for 18 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 4
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 1
  • Co-crystal Structure: 1
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 5
  • Phenotypic Enhancement: 2
  • Positive Genetic: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 196
Molecular Weight (Da) 22,141
Isoelectric Point (pI) 7.42
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:647038 to 646448 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..591 647038..646448 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006241
References cited on this page View Complete Literature Guide for ERV2
1) Stein G and Lisowsky T  (1998) Functional comparison of the yeast scERV1 and scERV2 genes. Yeast 14(2):171-80
2) Gerber J, et al.  (2001) Yeast ERV2p is the first microsomal FAD-linked sulfhydryl oxidase of the Erv1p/Alrp protein family. J Biol Chem 276(26):23486-91
3) Sevier CS, et al.  (2001) A flavoprotein oxidase defines a new endoplasmic reticulum pathway for biosynthetic disulphide bond formation. Nat Cell Biol 3(10):874-82
4) Lisowsky T  (1992) Dual function of a new nuclear gene for oxidative phosphorylation and vegetative growth in yeast. Mol Gen Genet 232(1):58-64