Standard Name	ERV14
Systematic Name	YGL054C
Feature Type	ORF, Verified
Description	COPII-coated vesicle protein; involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p to cell surface; related to Drosophila cornichon; ERV14 has a paralog, ERV15, that arose from the whole genome duplication (1, 2, 3)
Name Description	ER Vesicle

Chromosomal Location	ChrVII:401287 to 400871 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for ERV14
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	ascospore formation (IMP) axial cellular bud site selection (IMP) ER to Golgi vesicle-mediated transport (IMP, IPI)
Cellular Component
Manually curated	endoplasmic reticulum membrane (IDA) ER to Golgi transport vesicle (IDA)
High-throughput	integral to membrane (ISM)

Classical genetics
null	axial budding pattern: decreased tellurium atom accumulation: increased Tpo4p-GFP accumulation: abnormal resistance to FK506: decreased resistance to tellurite: decreased resistance to bathophenanthroline bisulfonate (BPS): decreased resistance to curcumin: decreased
Large-scale survey
null	auxotrophy glycogen accumulation: increased competitive fitness: decreased dessication resistance: decreased haploinsufficient heat sensitivity: increased resistance to bleomycin: decreased resistance to spermine: decreased resistance to hygromycin B: decreased resistance to pentachlorophenol: decreased resistance to neothyonidioside: decreased resistance to acetic acid: decreased resistance to ethanol: decreased resistance to sirolimus: decreased resistance to tunicamycin: increased resistance to hydroxyurea: increased resistance to sodium arsenite: increased resistance to wortmannin: increased resistance to camptothecin: decreased resistance to cycloheximide: decreased resistance to caffeine: decreased resistance to fenpropimorph: decreased resistance to mycophenolic acid: decreased resistance to dimethyl sulfoxide: decreased resistance to mefloquine: decreased resistance to clioquinol: decreased resistance to curcumin: decreased resistance to sorbate: decreased sporulation: absent stress resistance: decreased vacuolar morphology: abnormal viable
overexpression	cell cycle progression: abnormal vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	407 total interaction(s) for 206 unique genes/features.
Physical Interactions	Affinity Capture-MS: 19 Affinity Capture-RNA: 2 Affinity Capture-Western: 1 Co-fractionation: 1 Co-localization: 1 Co-purification: 1 PCA: 3 Reconstituted Complex: 1 Two-hybrid: 1
Genetic Interactions	Dosage Rescue: 3 Negative Genetic: 255 Phenotypic Enhancement: 9 Phenotypic Suppression: 61 Positive Genetic: 40 Synthetic Growth Defect: 4 Synthetic Lethality: 5
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:401287 to 400871 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..417 401287..400871 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003022