Standard Name	ERV1 1
Systematic Name	YGR029W
Feature Type	ORF, Verified
Description	Flavin-linked sulfhydryl oxidase of the mitochondrial IMS; N-terminus is an intrinsically disordered domain that in the cytosol helps target Erv1p to mitochondria, and in the intermembrane space oxidizes Mia40p as part of a disulfide relay system that promotes intermembrane space retention of imported proteins; ortholog of human hepatopoietin (ALR) (2, 3, 4, 5)
Name Description	Essential for Respiration and Viability 1

Chromosomal Location	ChrVII:543553 to 544205 | ORF Map | GBrowse

	View Computational GO annotations for ERV1
Molecular Function
Manually curated	flavin-linked sulfhydryl oxidase activity (IDA) thiol oxidase activity (IMP)
Biological Process
Manually curated	cellular iron ion homeostasis (IDA) cellular response to oxidative stress (IMP) protein import into mitochondrial intermembrane space (IMP)
Cellular Component
Manually curated	mitochondrial intermembrane space (IDA)
High-throughput	mitochondrion (IDA)

Classical genetics
conditional	heat sensitivity: increased mitochondrial transport: decreased
repressible	mitochondrial transport: decreased oxidative stress resistance: decreased Cmc1p distribution: abnormal
Large-scale survey
conditional	heat sensitivity: increased
null	haploproficient inviable vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	42 total interaction(s) for 20 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 3 Affinity Capture-Western: 9 Biochemical Activity: 8 Co-purification: 2 Reconstituted Complex: 8 Two-hybrid: 1
Genetic Interactions	Dosage Rescue: 2 Negative Genetic: 8 Synthetic Lethality: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:543553 to 544205 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 2000-07-14
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..86 543553..543638 2011-02-03 2000-07-14 Intron 87..169 543639..543721 2011-02-03 2000-07-14 CDS 170..653 543722..544205 2011-02-03 2000-07-14
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS) Intron (87 - 169)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003261