ERO1/YML130C Summary

ERO1 BASIC INFORMATION

Standard Name	ERO1
Systematic Name	YML130C
Feature Type	ORF, Verified
Description	Thiol oxidase required for oxidative protein folding in the endoplasmic reticulum (1, 2, 3)

GO Annotations	All ERO1 GO evidence and references
	View Computational GO annotations for ERO1
Molecular Function
Manually curated	electron carrier activity (IMP, ISS) thiol oxidase activity (IDA)
Biological Process
Manually curated	protein folding (IMP) protein thiol-disulfide exchange (IMP)
Cellular Component
Manually curated	endoplasmic reticulum (IDA)

Mutant Phenotype	All ERO1 Phenotype details and references
Classical genetics
misexpression	resistance to 1,4-dithiothreitol: decreased
Large-scale survey
null	inviable
overexpression	resistance to rapamycin: decreased vegetative growth: decreased

Interactions	ERO1 All interactions details and references
	20 total interaction(s) for 13 unique genes/features.
Physical Interactions	Affinity Capture-MS: 13 Affinity Capture-Western: 2
Genetic Interactions	Dosage Rescue: 2 Phenotypic Suppression: 1 Synthetic Growth Defect: 1 Synthetic Lethality: 1

Sequence Information

ChrXIII:13175 to 11484 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1692	13175..11484	1996-07-31	1996-07-31

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000004599

ERO1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for ERO1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for ERO1]

1)	Frand AR and Kaiser CA (1998) The ERO1 gene of yeast is required for oxidation of protein dithiols in the endoplasmic reticulum. Mol Cell 1(2):161-70
2)	Pollard MG, et al. (1998) Ero1p: a novel and ubiquitous protein with an essential role in oxidative protein folding in the endoplasmic reticulum. Mol Cell 1(2):171-82
3)	Gross E, et al. (2006) Generating disulfides enzymatically: reaction products and electron acceptors of the endoplasmic reticulum thiol oxidase Ero1p. Proc Natl Acad Sci U S A 103(2):299-304

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