Standard Name	ERG28
Systematic Name	YER044C
Alias	BUD18 1
Feature Type	ORF, Verified
Description	Endoplasmic reticulum membrane protein, may facilitate protein-protein interactions between the Erg26p dehydrogenase and the Erg27p 3-ketoreductase and/or tether these enzymes to the ER, also interacts with Erg6p (2, 3)
Name Description	ERGosterol biosynthesis

Chromosomal Location	ChrV:238016 to 237570 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for ERG28
Molecular Function
Manually curated	protein binding, bridging (IPI)
Biological Process
Manually curated	ergosterol biosynthetic process (IDA, IMP, IPI)
Cellular Component
Manually curated	endoplasmic reticulum membrane (IDA)

Classical genetics
null	sterol accumulation: abnormal vegetative growth: decreased rate
Large-scale survey
null	UV resistance: decreased budding pattern: abnormal cell shape: abnormal cell size: decreased proton accumulation: increased proton accumulation: decreased inositol excretion: increased competitive fitness: decreased fermentative growth: decreased rate heat sensitivity: increased mitochondrial morphology: abnormal oxidative stress resistance: decreased resistance to cycloheximide: decreased resistance to paromomycin: decreased resistance to streptomycin: decreased resistance to fluconazole: increased resistance to sulfanilamide: decreased resistance to tetracycline: decreased resistance to oxytetracycline: decreased resistance to ethanol: decreased resistance to camptothecin: decreased resistance to hydroxyurea: decreased resistance to caffeine: decreased resistance to acetic acid: decreased resistance to hydrogen chloride: decreased resistance to methyl methanesulfonate: decreased resistance to 4-nitroquinoline N-oxide: decreased resistance to 4-chlorophenol: decreased resistance to 2,4-dichlorophenol: decreased resistance to mefloquine: decreased resistance to monensin: decreased resistance to hygromycin B: decreased resistance to St. John's Wort extract: decreased starvation resistance: decreased vacuolar morphology: abnormal vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	69 total interaction(s) for 25 unique genes/features.
Physical Interactions	Affinity Capture-MS: 1 Affinity Capture-RNA: 3 Affinity Capture-Western: 29 PCA: 17 Two-hybrid: 8
Genetic Interactions	Negative Genetic: 1 Synthetic Lethality: 7 Synthetic Rescue: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrV:238016 to 237570 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..447 238016..237570 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000846