ERG28/YER044C Summary Help

Standard Name ERG28 1
Systematic Name YER044C
Alias BUD18 2
Feature Type ORF, Verified
Description Endoplasmic reticulum membrane protein; may facilitate protein-protein interactions between the Erg26p dehydrogenase and the Erg27p 3-ketoreductase and/or tether these enzymes to the ER, also interacts with Erg6p (3, 4)
Name Description ERGosterol biosynthesis 1
Chromosomal Location
ChrV:238016 to 237570 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All ERG28 GO evidence and references
  View Computational GO annotations for ERG28
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 6 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
Resources
56 total interaction(s) for 28 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-RNA: 4
  • Affinity Capture-Western: 13
  • PCA: 18
  • Two-hybrid: 8

Genetic Interactions
  • Negative Genetic: 1
  • Synthetic Lethality: 7
  • Synthetic Rescue: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 148
Molecular Weight (Da) 17,135
Isoelectric Point (pI) 10.2
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrV:238016 to 237570 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..447 238016..237570 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000846
References cited on this page View Complete Literature Guide for ERG28
1) Hughes TR, et al.  (2000) Functional discovery via a compendium of expression profiles. Cell 102(1):109-26
2) Ni L and Snyder M  (2001) A genomic study of the bipolar bud site selection pattern in Saccharomyces cerevisiae. Mol Biol Cell 12(7):2147-70
3) Gachotte D, et al.  (2001) A novel gene conserved from yeast to humans is involved in sterol biosynthesis. J Lipid Res 42(1):150-4
4) Mo C, et al.  (2004) The ERG28-encoded protein, Erg28p, interacts with both the sterol C-4 demethylation enzyme complex as well as the late biosynthetic protein, the C-24 sterol methyltransferase (Erg6p). Biochim Biophys Acta 1686(1-2):30-6