ERG26/YGL001C Summary 
| Standard Name | ERG26 |
|---|---|
| Systematic Name | YGL001C |
| Feature Type | ORF, Verified |
| Description | C-3 sterol dehydrogenase, catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis (1, 2, 3, 4 and see Summary Paragraph) |
| Name Description | ERGosterol biosynthesis |
| Chromosomal Location | |
|---|---|
| Note: this feature is encoded on the Crick strand. | |
|
Gene Ontology Annotations All ERG26 GO evidence and references
| View Computational GO annotations for ERG26 | |
| Molecular Function | |
| Manually curated | |
| Biological Process | |
| Manually curated | |
| Cellular Component | |
| Manually curated |
| Pathways |
|---|
Mutant phenotypes All ERG26 Phenotype evidence and references
| Classical genetics | |
|---|---|
| repressible | |
| Large-scale survey | |
| null | |
| reduction of function | |
| repressible |
|
| Resources |
interactions All ERG26 Interaction evidence and references
| 100 total interaction(s) for 73 unique genes/features. | |
| Physical Interactions |
|
| Genetic Interactions |
|
| Resources |
|
Expression Summary
|
| |
| Resources |
Protein Information All ERG26 Protein evidence and references
| Localization | |
|---|---|
| Phosphorylation | PhosphoGRID | PhosphoPep Database |
| Structure | |
| Homologs |
sequence information
| Note: this feature is encoded on the Crick strand. | |||||||||||||
|
| |||||||||||||
| Last Update | Coordinates: 2011-02-03 | Sequence: 1996-07-31 | ||||||||||||
| Subfeature details |
| ||||||||||||
| Retrieve sequences | |||||||||||||
Analyze Sequence
| S288C only | |
|---|---|
| S288C vs. other species | |
| S288C vs. other strains |
Resources
| External Links | All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB |
|---|
| Primary SGDID | S000002969 |
|---|
SUMMARY PARAGRAPH for ERG26
ERG26 encodes C-3 sterol dehydrogenase, an enzyme that catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis (3, 4, 1, 2). The enzyme removes the 3-alpha-hydrogen, resulting in the decarboxylation of the 3-ketocarboxylic acid sterol intermediate (3). Cells lacking ERG26 are inviable (3). Mutations in ERG1, which encodes squalene monooxygenase, or in HEM1 or HEM3, which encode heme biosynthetic enzymes, can partially suppress the erg26 null phenotype. The erg26 hem1, erg26 hem3, and erg26 erg1 double mutants can grow if supplemented with ergosterol, and accumulate nonesterified carboxylic acid sterols (3).
Last updated: 2000-09-01 
References cited on this page View Complete Literature Guide for ERG26
| 1) | Lees ND, et al. (1995) Cloning of the late genes in the ergosterol biosynthetic pathway of Saccharomyces cerevisiae--a review. Lipids 30(3):221-6 |
| 2) | Parks LW, et al. (1995) Biochemical and physiological effects of sterol alterations in yeast--a review. Lipids 30(3):227-30 |
| 3) | Gachotte D, et al. (1998) Characterization of the Saccharomyces cerevisiae ERG26 gene encoding the C-3 sterol dehydrogenase (C-4 decarboxylase) involved in sterol biosynthesis. Proc Natl Acad Sci U S A 95(23):13794-9 |
| 4) | Paltauf F, et al. (1992) "Regulation and compartmentalization of lipid synthesis in yeast." Pp. 415-500 in The Molecular and Cellular Biology of the Yeast Saccharomyces: Gene Expression, edited by Jones EW, Pringle JR and Broach JR. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press |
