ERG20/YJL167W Summary 
ERG20 BASIC INFORMATION
| Standard Name | ERG20 1 |
|---|---|
| Systematic Name | YJL167W |
| Alias | BOT3 , FDS1 , FPP1 |
| Feature Type | ORF, Verified |
| Description | Farnesyl pyrophosphate synthetase, has both dimethylallyltranstransferase and geranyltranstransferase activities; catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis (2, 3 and see Summary Paragraph) 
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| Name Description | ERGosterol biosynthesis 1 |
| GO Annotations | All ERG20 GO evidence and references |
|---|---|
| View Computational GO annotations for ERG20 | |
| Molecular Function | |
| Manually curated | |
| Biological Process | |
| Manually curated | |
| Cellular Component | |
| Manually curated |
| Pathways |
|---|
| Mutant Phenotype | All ERG20 Phenotype details and references |
|---|---|
| Classical genetics | |
| null | |
| Large-scale survey | |
| null |
| Interactions | ERG20 All interactions details and references |
|---|---|
| 22 total interaction(s) for 20 unique genes/features. | |
| Physical Interactions |
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| Genetic Interactions |
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| External Links | All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB |
|---|
| Primary SGDID | S000003703 |
|---|
ERG20 RESOURCES
| SGD ORF map | GBrowse |
|---|---|
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Click on histogram for expression summary
Expression Summary
ADDITIONAL INFORMATION for ERG20
SUMMARY PARAGRAPH for ERG20
ERG20 encodes farnesyl pyrophosphate synthetase (FPP synthase), a cytosolic enzyme that has dimethylallyltranstransferase and geranyltranstransferase activities (3, 2, 4). FPP synthase catalyzes the sequential 1'-4 coupling of isopentenyl diphosphate (IPP) with dimethylallyl diphosphate and geranyl diphosphate, forming C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis; in yeast ergosterol is the end product of the sterol biosynthetic pathway (3, 5, 4).
ERG20 is essential; erg20 mutations cause ergosterol auxotrophy, and erg20 mutant cells excrete prenyl alcohols (3, 6). FPP synthases have been identified in many organisms (3, 7, 4); the Arabidopsis gene FPS1 can complement the yeast erg20 null phenotype (8).
Last updated: 2000-08-28
REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for ERG20]
| 1) | Chambon C, et al. (1991) Sterol pathway in yeast. Identification and properties of mutant strains defective in mevalonate diphosphate decarboxylase and farnesyl diphosphate synthetase. Lipids 26(8):633-6 |
| 2) | Parks LW, et al. (1995) Biochemical and physiological effects of sterol alterations in yeast--a review. Lipids 30(3):227-30 |
| 3) | Anderson MS, et al. (1989) Farnesyl diphosphate synthetase. Molecular cloning, sequence, and expression of an essential gene from Saccharomyces cerevisiae. J Biol Chem 264(32):19176-84 |
| 4) | Stryer L (1995) Biochemistry (4th ed.). New York: W. H. Freeman and Company |
| 5) | Paltauf F, et al. (1992) "Regulation and compartmentalization of lipid synthesis in yeast." Pp. 415-500 in The Molecular and Cellular Biology of the Yeast Saccharomyces: Gene Expression, edited by Jones EW, Pringle JR and Broach JR. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press |
| 6) | Chambon C, et al. (1990) Isolation and properties of yeast mutants affected in farnesyl diphosphate synthetase. Curr Genet 18(1):41-6 |
| 7) | Ohnuma S, et al. (1997) Conversion from archaeal geranylgeranyl diphosphate synthase to farnesyl diphosphate synthase. Two amino acids before the first aspartate-rich motif solely determine eukaryotic farnesyl diphosphate synthase activity. J Biol Chem 272(8):5192-8 |
| 8) | Cunillera N, et al. (1996) Arabidopsis thaliana contains two differentially expressed farnesyl-diphosphate synthase genes. J Biol Chem 271(13):7774-80 |
