SUMMARY PARAGRAPH for ERG10
ERG10 encodes acetyl-CoA C-acetyltransferase (also called acetoacetyl-CoA thiolase), a cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA (1, 3). The formation of acetoacetyl-CoA is the first step in the biosynthesis of mevalonate, which is required in turn for the biosynthesis of sterols and nonsterol isoprenoids (3); in yeast, ergosterol is the end product of the sterol biosynthetic pathway (4, 5).
Cells lacking Erg10p are viable but lack detectable acetyl-CoA C-acetyltransferase and are mevalonate auxotrophs (1). Expression of ERG10 is regulated by a sterol-mediated feedback system (6).
Enzymes similar to Erg10p are found in many diverse organisms (1); the enzymes from Saccharomyces uvarum and radish can complement S. cerevisiae erg10 mutants (7, 8).
Last updated: 2000-08-21