ERF2/YLR246W Summary Help

Standard Name ERF2 1
Systematic Name YLR246W
Feature Type ORF, Verified
Description Subunit of a palmitoyltransferase; this complex adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; mutants partially mislocalize Ras2p to the vacuole; palmitoyltransferase is composed of Erf2p and Shr5p (1, 2, 3)
Name Description Effect on Ras Function 1
Chromosomal Location
ChrXII:627118 to 628197 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All ERF2 GO evidence and references
  View Computational GO annotations for ERF2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 5 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
61 total interaction(s) for 41 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 2
  • Biochemical Activity: 3
  • Co-localization: 1
  • PCA: 2
  • Two-hybrid: 2

Genetic Interactions
  • Dosage Growth Defect: 1
  • Negative Genetic: 36
  • Positive Genetic: 7
  • Synthetic Lethality: 3
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 359
Molecular Weight (Da) 41,099
Isoelectric Point (pI) 10.12
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:627118 to 628197 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1080 627118..628197 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004236
References cited on this page View Complete Literature Guide for ERF2
1) Bartels DJ, et al.  (1999) Erf2, a novel gene product that affects the localization and palmitoylation of Ras2 in Saccharomyces cerevisiae. Mol Cell Biol 19(10):6775-87
2) Lobo S, et al.  (2002) Identification of a Ras palmitoyltransferase in Saccharomyces cerevisiae. J Biol Chem 277(43):41268-73
3) Roth AF, et al.  (2006) Global analysis of protein palmitoylation in yeast. Cell 125(5):1003-13