EPL1/YFL024C Summary Help

Standard Name EPL1 1
Systematic Name YFL024C
Feature Type ORF, Verified
Description Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex; conserved region at N-terminus is essential for interaction with the NPC (nucleosome core particle); required for autophagy; homologous to Drosophila Enhancer of Polycomb; coding sequence contains length polymorphisms in different strains (1, 2, 3, 4, 5)
Name Description Enhancer of Polycomb Like 1
Chromosomal Location
ChrVI:90345 to 87847 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All EPL1 GO evidence and references
  View Computational GO annotations for EPL1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 13 genes
Resources
Classical genetics
conditional
null
reduction of function
repressible
Large-scale survey
null
overexpression
reduction of function
repressible
Resources
336 total interaction(s) for 196 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 66
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 58
  • Biochemical Activity: 2
  • Co-crystal Structure: 12
  • Co-purification: 1
  • Reconstituted Complex: 3
  • Two-hybrid: 2

Genetic Interactions
  • Synthetic Growth Defect: 112
  • Synthetic Lethality: 71
  • Synthetic Rescue: 7

Resources
Expression Summary
histogram
Resources
Length (a.a.) 832
Molecular Weight (Da) 96,737
Isoelectric Point (pI) 9.38
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVI:90345 to 87847 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2499 90345..87847 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001870
References cited on this page View Complete Literature Guide for EPL1
1) Stankunas K, et al.  (1998) The enhancer of polycomb gene of Drosophila encodes a chromatin protein conserved in yeast and mammals. Development 125(20):4055-66
2) Galarneau L, et al.  (2000) Multiple links between the NuA4 histone acetyltransferase complex and epigenetic control of transcription. Mol Cell 5(6):927-37
3) Chittuluru JR, et al.  (2011) Structure and nucleosome interaction of the yeast NuA4 and Piccolo-NuA4 histone acetyltransferase complexes.LID - 10.1038/nsmb.2128 [doi] Nat Struct Mol Biol ()
4) Yi C, et al.  (2012) Function and molecular mechanism of acetylation in autophagy regulation. Science 336(6080):474-7
5) Carvalho-Netto OV, et al.  (2013) A simple and effective set of PCR-based molecular markers for the monitoring of the Saccharomyces cerevisiae cell population during bioethanol fermentation. J Biotechnol 168(4):701-9