Standard Name	EOS1 1
Systematic Name	YNL080C
Feature Type	ORF, Verified
Description	Protein involved in N-glycosylation; deletion mutation confers sensitivity to exidative stress and shows synthetic lethality with mutations in the spindle checkpoint genes BUB3 and MAD1; YNL080C is not an essential gene (1, 2, 3, 4)
Name Description	ER-localized and Oxidants Sensitive 1

Chromosomal Location	ChrXIV:478032 to 476932 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for EOS1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	cellular response to oxidative stress (IMP) protein N-linked glycosylation (IMP)
Cellular Component
Manually curated	endoplasmic reticulum membrane (IDA)
High-throughput	integral to membrane (ISM)

Classical genetics
null	tellurium atom accumulation: increased chromosome/plasmid maintenance: abnormal metal resistance: decreased oxidative stress resistance: decreased Ccw14p distribution: abnormal Hsp150p distribution: abnormal Cwp1p distribution: abnormal carboxypeptidase Y (Prc1p) modification: decreased resistance to tunicamycin: increased resistance to tellurite: decreased vegetative growth: decreased
Large-scale survey
null	auxotrophy competitive fitness: decreased freeze-thaw resistance: decreased heat sensitivity: increased metal resistance: decreased oxidative stress resistance: decreased protein transport: abnormal resistance to hydroxyurea: increased resistance to tacrolimus (anhydrous) and tunicamycin: increased resistance to caspofungin: increased resistance to mycophenolic acid: increased resistance to tunicamycin: increased resistance to 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid: decreased resistance to camptothecin: increased resistance to 1,4-dithiothreitol and tacrolimus (anhydrous): increased resistance to fluconazole: increased resistance to fenpropimorph: increased resistance to calcium dichloride: decreased resistance to caffeine: decreased resistance to cycloheximide: decreased resistance to sirolimus: decreased resistance to benzo[a]pyrene: decreased resistance to methyl methanesulfonate: decreased resistance to farnesol: decreased resistance to monensin: decreased resistance to pyrrolidine dithiocarbamate: decreased resistance to bleomycin: decreased respiratory growth: decreased rate respiratory growth: absent sporulation: normal starvation resistance: decreased utilization of carbon source: decreased utilization of iron source: decreased vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	195 total interaction(s) for 185 unique genes/features.
Physical Interactions	Biochemical Activity: 1 Protein-RNA: 1
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 133 Phenotypic Enhancement: 9 Phenotypic Suppression: 15 Positive Genetic: 19 Synthetic Growth Defect: 9 Synthetic Lethality: 3 Synthetic Rescue: 4
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIV:478032 to 476932 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1101 478032..476932 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005024