ENT5/YDR153C Summary

ENT5 BASIC INFORMATION

Standard Name	ENT5 1
Systematic Name	YDR153C
Feature Type	ORF, Verified
Description	Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p, clathrin adaptor complex AP-1, and clathrin (1, 2)
Name Description	Epsin N-Terminal homology 1

GO Annotations	All ENT5 GO evidence and references
	View Computational GO annotations for ENT5
Molecular Function
Manually curated	clathrin binding (IPI) phosphatidylinositol-3,5-bisphosphate binding (IDA, IMP)
Biological Process
Manually curated	Golgi to endosome transport (IMP) late endosome to vacuole transport via multivesicular body sorting pathway (IMP)
Cellular Component
Manually curated	clathrin vesicle coat (IDA) endosome (IDA)
High-throughput	cytoplasm (IDA)

Mutant Phenotype	All ENT5 Phenotype details and references
Large-scale survey
null	competitive fitness: decreased viable
overexpression	vegetative growth: decreased

Interactions	ENT5 All interactions details and references
	View additional details at BioGRID
	122 total interaction(s) for 85 unique genes/features.
Physical Interactions	Affinity Capture-MS: 12 Affinity Capture-Western: 5 Biochemical Activity: 6 Reconstituted Complex: 2 Two-hybrid: 2
Genetic Interactions	Negative Genetic: 76 Phenotypic Enhancement: 1 Positive Genetic: 8 Synthetic Growth Defect: 4 Synthetic Haploinsufficiency: 1 Synthetic Lethality: 4 Synthetic Rescue: 1

Sequence Information

ChrIV:767969 to 766734 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2008-06-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1236	767969..766734	2008-06-05	1996-07-31

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000002560

ENT5 RESOURCES

Click on map for expanded view

SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for ENT5

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for ENT5]

1)	Duncan MC, et al. (2003) Yeast epsin-related proteins required for Golgi-endosome traffic define a gamma-adaptin ear-binding motif. Nat Cell Biol 5(1):77-81
2)	Wendland B, et al. (1999) Yeast epsins contain an essential N-terminal ENTH domain, bind clathrin and are required for endocytosis. EMBO J 18(16):4383-93

SGD^tm pages Database Copyright © 1997-2010 The Board of Trustees of Leland Stanford Junior University. Permission to use the information contained in this database was given by the researchers/institutes who contributed or published the information. Users of the database are solely responsible for compliance with any copyright restrictions, including those applying to the author abstracts. Documents from this server are provided "AS-IS" without any warranty, expressed or implied. The SGD project at Stanford University is supported by a Genome Research Resource Grant from the US National Human Genome Research Institute, part of the US National Institutes of Health.