SUMMARY PARAGRAPH for ELP4
Elp4p is part of the six-subunit Elongator complex, which is a major histone acetyltransferase component of the RNA polymerase II holoenzyme responsible for transcriptional elongation (9, 10, 3). Elongator contains two discrete subcomplexes, one consisting of Iki3p/Elp1p, Elp2p, and Elp3p, and the other consisting of Elp4p, Iki1p/Elp5p, and Elp6p (1, 2). Elongator binds to both naked and nucleosomal DNA, can acetylate both core histones and nucleosomal substrates, and plays a role in chromatin remodeling (11, 5). Its activity is directed specifically toward the amino-terminal tails of histone H3 and H4, with the predominant acetylation sites being lysine-14 of histone H3 and lysine-8 of histone H4 (5).
Of the six Elongator subunits, only Iki1p/Elp5p is essential for growth, and deletion of the other individual subunits causes significantly altered mRNA expression levels for many genes (2). Disruption of the Elongator complex confers resistance to the Kluyveromyces lactis zymotoxin (6), and a reduced sensitivity to the Pichia inositovora toxin (12).
Last updated: 2004-05-12