SUMMARY PARAGRAPH for ELM1
Elm1p is a serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis (3, 5, 2). Elm1p is required for the normal hyperphosphorylation of the Swe1p kinase during mitosis, and for the proper regulation of a number of other kinases, including Snf1p, Cla4p, and Gin4p (4). Elm1p interacts genetically with Cla4p, Gin4p, and the mitotic cyclins (4).
Elm1p is localized at the bud neck in a septin-dependent fashion from bud emergence until the completion of anaphase, at about the time of cell division (2). Elm1p forms part of the bud neck ring, and is required for the localization of Hsl1p and Cdc12p to the bud neck ring (6).
Strains mutant in Elm1p display ectopic localization of Cdc12p at the bud tip (6), delayed cytokinesis (2), failure to negatively regulate polar bud growth during mitosis, and defects in septin organization (4). Deletion results in constitutive filamentous growth (7); overexpression causes elongated bud formation (8).
Last updated: 2004-04-15