ELC1/YPL046C Summary Help

Standard Name ELC1 1
Systematic Name YPL046C
Feature Type ORF, Verified
Description Elongin C, conserved among eukaryotes; forms a complex with Cul3p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; plays a role in global genomic repair (1, 2, 3, 4, 5, 6)
Name Description ELongin C 1
Chromosomal Location
ChrXVI:466943 to 466644 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gene Ontology Annotations All ELC1 GO evidence and references
  View Computational GO annotations for ELC1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 2 genes
Classical genetics
Large-scale survey
78 total interaction(s) for 50 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 6
  • Affinity Capture-Western: 11
  • Biochemical Activity: 1
  • Co-purification: 5
  • Reconstituted Complex: 5
  • Two-hybrid: 3

Genetic Interactions
  • Negative Genetic: 34
  • Phenotypic Enhancement: 2
  • Positive Genetic: 4
  • Synthetic Growth Defect: 4
  • Synthetic Rescue: 3

Expression Summary
Length (a.a.) 99
Molecular Weight (Da) 11,328
Isoelectric Point (pI) 4.18
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrXVI:466943 to 466644 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..300 466943..466644 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005967
References cited on this page View Complete Literature Guide for ELC1
1) Botuyan MV, et al.  (1999) Binding of elongin A or a von Hippel-Lindau peptide stabilizes the structure of yeast elongin C. Proc Natl Acad Sci U S A 96(16):9033-8
2) Aso T and Conrad MN  (1997) Molecular cloning of DNAs encoding the regulatory subunits of elongin from Saccharomyces cerevisiae and Drosophila melanogaster. Biochem Biophys Res Commun 241(2):334-40
3) Hyman LE, et al.  (2002) Binding to Elongin C inhibits degradation of interacting proteins in yeast. J Biol Chem 277(18):15586-91
4) Ribar B, et al.  (2007) ELA1 and CUL3 are required along with ELC1 for RNA polymerase II polyubiquitylation and degradation in DNA-damaged yeast cells. Mol Cell Biol 27(8):3211-6
5) Lejeune D, et al.  (2009) Yeast Elc1 plays an important role in global genomic repair but not in transcription coupled repair. DNA Repair (Amst) 8(1):40-50
6) Harreman M, et al.  (2009) Distinct ubiquitin ligases act sequentially for RNA polymerase II polyubiquitylation. Proc Natl Acad Sci U S A 106(49):20705-10