EGD2/YHR193C Summary

EGD2 BASIC INFORMATION

Standard Name	EGD2 1
Systematic Name	YHR193C
Feature Type	ORF, Verified
Description	Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes (1, 2, 3)
Name Description	Enhancer of Gal4 DNA binding 1

GO Annotations	All EGD2 GO evidence and references
	View Computational GO annotations for EGD2
Molecular Function
Manually curated	phosphatidic acid binding (IDA) phosphatidylinositol 3-phosphate binding (IDA) phosphatidylinositol-3,5-bisphosphate binding (IDA) phosphatidylinositol-4-phosphate binding (IDA) unfolded protein binding (IMP)
Biological Process
Manually curated	'de novo' cotranslational protein folding (IPI)
Cellular Component
Manually curated	nascent polypeptide-associated complex (IDA)

Mutant Phenotype	All EGD2 Phenotype details and references
Classical genetics
null	mitochondrial genome maintenance: abnormal mitochondrial transport: abnormal resistance to adriamycin: decreased respiratory growth: decreased rate
Large-scale survey
null	resistance to methyl methanesulfonate: decreased viable

Interactions	EGD2 All interactions details and references
	38 total interaction(s) for 29 unique genes/features.
Physical Interactions	Affinity Capture-MS: 22 Affinity Capture-RNA: 1 Affinity Capture-Western: 5 Co-fractionation: 1 Two-hybrid: 7
Genetic Interactions	Phenotypic Enhancement: 1 Synthetic Lethality: 1

Sequence Information

ChrVIII:488236 to 487712 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2005-11-07 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..525	488236..487712	2005-11-07	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000001236

EGD2 RESOURCES

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SGD ORF map	GBrowse

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Expression Summary

ADDITIONAL INFORMATION for EGD2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for EGD2]

1)	Shi X, et al. (1995) The yeast EGD2 gene encodes a homologue of the alpha NAC subunit of the human nascent-polypeptide-associated complex. Gene 165(2):199-202
2)	George R, et al. (1998) The yeast nascent polypeptide-associated complex initiates protein targeting to mitochondria in vivo. Proc Natl Acad Sci U S A 95(5):2296-301
3)	Reimann B, et al. (1999) Initial characterization of the nascent polypeptide-associated complex in yeast. Yeast 15(5):397-407

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