Standard Name	EGD1 1
Systematic Name	YPL037C
Feature Type	ORF, Verified
Description	Subunit beta1 of the nascent polypeptide-associated complex (NAC); involved in protein targeting, associated with cytoplasmic ribosomes; enhances DNA binding of the Gal4p activator; homolog of human BTF3b; EGD1 has a paralog, BTT1, that arose from the whole genome duplication (2, 3, 4, 5, 6)
Name Description	Enhancer of Gal4 DNA binding 1

Chromosomal Location	ChrXVI:481901 to 481428 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for EGD1
Molecular Function
Manually curated	unfolded protein binding (IMP)
Biological Process
Manually curated	'de novo' cotranslational protein folding (IPI)
Cellular Component
Manually curated	nascent polypeptide-associated complex (IDA)

Classical genetics
null	GAL10 mRNA accumulation: decreased autophagy: decreased mitophagy: decreased resistance to staurosporine: decreased resistance to tunicamycin: decreased resistance to Calcofluor White: decreased resistance to chlorpromazine: decreased resistance to adriamycin: decreased resistance to bleomycin: decreased viable
Large-scale survey
null	glutathione excretion: increased competitive fitness: decreased resistance to amitrole: decreased resistance to nickel(2+): decreased resistance to cycloheximide: decreased resistance to doxorubicin: decreased resistance to 1,4-dithiothreitol: decreased respiratory growth: absent stress resistance: increased vegetative growth: decreased rate viable
overexpression	colony sectoring: increased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	116 total interaction(s) for 83 unique genes/features.
Physical Interactions	Affinity Capture-MS: 14 Affinity Capture-RNA: 4 Affinity Capture-Western: 9 Co-fractionation: 3 Co-purification: 6 PCA: 3 Two-hybrid: 12
Genetic Interactions	Negative Genetic: 48 Phenotypic Enhancement: 1 Positive Genetic: 8 Synthetic Growth Defect: 3 Synthetic Lethality: 4 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXVI:481901 to 481428 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..474 481901..481428 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005958