EFT1/YOR133W Summary

EFT1 BASIC INFORMATION

Standard Name	EFT1 1
Systematic Name	YOR133W
Feature Type	ORF, Verified
Description	Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin (1, 2, 3)
Name Description	Elongation Factor Two 3

GO Annotations	All EFT1 GO evidence and references
	View Computational GO annotations for EFT1
Molecular Function
Manually curated	translation elongation factor activity (TAS)
Biological Process
Manually curated	translational elongation (TAS)
Cellular Component
Manually curated	ribosome (TAS)

Mutant Phenotype	All EFT1 Phenotype details and references
Large-scale survey
null	filamentous growth: decreased invasive growth: absent viable
overexpression	vegetative growth: decreased

Interactions	EFT1 All interactions details and references
	65 total interaction(s) for 58 unique genes/features.
Physical Interactions	Affinity Capture-MS: 55 PCA: 3
Genetic Interactions	Phenotypic Enhancement: 3 Phenotypic Suppression: 3 Synthetic Lethality: 1

Sequence Information

ChrXV:575099 to 577627 | |

Last Update

Coordinates: 2006-01-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2529	575099..577627	2006-01-05	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000005659

EFT1 RESOURCES

Click on map for expanded view

SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for EFT1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for EFT1]

1)	Perentesis JP, et al. (1992) Saccharomyces cerevisiae elongation factor 2. Genetic cloning, characterization of expression, and G-domain modeling. J Biol Chem 267(2):1190-7
2)	Justice MC, et al. (1998) Elongation factor 2 as a novel target for selective inhibition of fungal protein synthesis. J Biol Chem 273(6):3148-51
3)	Dunlop PC and Bodley JW (1983) Biosynthetic labeling of diphthamide in Saccharomyces cerevisiae. J Biol Chem 258(8):4754-8

SGD^tm pages Database Copyright © 1997-2010 The Board of Trustees of Leland Stanford Junior University. Permission to use the information contained in this database was given by the researchers/institutes who contributed or published the information. Users of the database are solely responsible for compliance with any copyright restrictions, including those applying to the author abstracts. Documents from this server are provided "AS-IS" without any warranty, expressed or implied. The SGD project at Stanford University is supported by a Genome Research Resource Grant from the US National Human Genome Research Institute, part of the US National Institutes of Health.