EFB1/YAL003W Summary Help

Standard Name EFB1 1
Systematic Name YAL003W
Alias TEF5
Feature Type ORF, Verified
Description Translation elongation factor 1 beta; stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex, which facilitates binding of aminoacyl-tRNA to the ribosomal A site (2)
Name Description Elongation Factor Beta 1
Gene Product Alias EF-1beta 1 , eEF1Balpha 3
Chromosomal Location
ChrI:142174 to 143160 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All EFB1 GO evidence and references
  View Computational GO annotations for EFB1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 20 genes
Resources
Classical genetics
dominant negative
null
reduction of function
unspecified
Large-scale survey
null
reduction of function
unspecified
Resources
75 total interaction(s) for 57 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 20
  • Affinity Capture-RNA: 8
  • Affinity Capture-Western: 3
  • Co-crystal Structure: 4
  • PCA: 2
  • Two-hybrid: 2

Genetic Interactions
  • Dosage Rescue: 3
  • Negative Genetic: 25
  • Positive Genetic: 3
  • Synthetic Lethality: 5

Resources
Expression Summary
histogram
Resources
Length (a.a.) 206
Molecular Weight (Da) 22,627
Isoelectric Point (pI) 4.13
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrI:142174 to 143160 | ORF Map | GBrowse
This feature contains embedded feature(s): SNR18
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..80 142174..142253 2011-02-03 1999-07-17
Intron 81..446 142254..142619 2011-02-03 1999-07-17
CDS 447..987 142620..143160 2011-02-03 1999-07-17
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000003
References cited on this page View Complete Literature Guide for EFB1
1) Hiraga K, et al.  (1993) Cloning and characterization of the elongation factor EF-1 beta homologue of Saccharomyces cerevisiae. EF-1 beta is essential for growth. FEBS Lett 316(2):165-9
2) Kinzy TG and Woolford JL Jr  (1995) Increased expression of Saccharomyces cerevisiae translation elongation factor 1 alpha bypasses the lethality of a TEF5 null allele encoding elongation factor 1 beta. Genetics 141(2):481-9
3) Pittman YR, et al.  (2009) Coordination of eukaryotic translation elongation factor 1A (eEF1A) function in actin organization and translation elongation by the guanine nucleotide exchange factor eEF1Balpha. J Biol Chem 284(7):4739-47