EFB1/YAL003W Summary

EFB1 BASIC INFORMATION

Standard Name	EFB1
Systematic Name	YAL003W
Alias	TEF5
Feature Type	ORF, Verified
Description	Translation elongation factor 1 beta; stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex, which facilitates binding of aminoacyl-tRNA to the ribosomal A site (1)
Name Description	Elongation Factor Beta 2

GO Annotations	All EFB1 GO evidence and references
	View Computational GO annotations for EFB1
Molecular Function
Manually curated	guanyl-nucleotide exchange factor activity (IDA) translation elongation factor activity (TAS)
Biological Process
Manually curated	translational elongation (TAS)
Cellular Component
Manually curated	eukaryotic translation elongation factor 1 complex (IMP, ISS) ribosome (TAS)

Mutant Phenotype	All EFB1 Phenotype details and references
Large-scale survey
null	filamentous growth: increased invasive growth: absent inviable

Interactions	EFB1 All interactions details and references
	55 total interaction(s) for 43 unique genes/features.
Physical Interactions	Affinity Capture-MS: 13 Affinity Capture-RNA: 1 Affinity Capture-Western: 2 Co-crystal Structure: 4 Two-hybrid: 2
Genetic Interactions	Dosage Rescue: 3 Phenotypic Enhancement: 25 Phenotypic Suppression: 3 Synthetic Lethality: 2

Sequence Information

ChrI:142176 to 143162 | |

This feature contains embedded feature(s): SNR18

Last Update

Coordinates: 2004-07-20 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..80	142176..142255	2004-07-20	1999-07-17
Intron	81..446	142256..142621	2004-07-20	1999-07-17
CDS	447..987	142622..143162	2004-07-20	1999-07-17

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000000003

EFB1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for EFB1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for EFB1]

1)	Kinzy TG and Woolford JL Jr (1995) Increased expression of Saccharomyces cerevisiae translation elongation factor 1 alpha bypasses the lethality of a TEF5 null allele encoding elongation factor 1 beta. Genetics 141(2):481-9
2)	Hiraga K, et al. (1993) Cloning and characterization of the elongation factor EF-1 beta homologue of Saccharomyces cerevisiae. EF-1 beta is essential for growth. FEBS Lett 316(2):165-9

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