ECM38/YLR299W Summary Help

Standard Name ECM38 1
Systematic Name YLR299W
Alias CIS2 2
Feature Type ORF, Verified
Description Gamma-glutamyltranspeptidase; major glutathione-degrading enzyme; involved in detoxification of electrophilic xenobiotics; expression induced mainly by nitrogen starvation (3, 4, 5, 6)
Name Description ExtraCellular Mutant
Chromosomal Location
ChrXII:726069 to 728051 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All ECM38 GO evidence and references
  View Computational GO annotations for ECM38
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 7 genes
Resources
Pathways
Classical genetics
null
Large-scale survey
null
unspecified
Resources
22 total interaction(s) for 18 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 1

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 12
  • Positive Genetic: 4
  • Synthetic Growth Defect: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 660
Molecular Weight (Da) 73,180
Isoelectric Point (pI) 5.75
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:726069 to 728051 | ORF Map | GBrowse
This feature contains embedded feature(s): YLR299C-A
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1983 726069..728051 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004290
References cited on this page View Complete Literature Guide for ECM38
1) Lussier M, et al.  (1997) Large scale identification of genes involved in cell surface biosynthesis and architecture in Saccharomyces cerevisiae. Genetics 147(2):435-50
2) Manning BD, et al.  (1997) The Rho-GEF Rom2p localizes to sites of polarized cell growth and participates in cytoskeletal functions in Saccharomyces cerevisiae. Mol Biol Cell 8(10):1829-44
3) Kumar C, et al.  (2003) Utilization of glutathione as an exogenous sulfur source is independent of gamma-glutamyl transpeptidase in the yeast Saccharomyces cerevisiae: evidence for an alternative gluathione degradation pathway. FEMS Microbiol Lett 219(2):187-94
4) Springael JY and Penninckx MJ  (2003) Nitrogen-source regulation of yeast gamma-glutamyl transpeptidase synthesis involves the regulatory network including the GATA zinc-finger factors Gln3, Nil1/Gat1 and Gzf3. Biochem J 371(Pt 2):589-95
5) Kumar C, et al.  (2003) Investigations into the polymorphisms at the ECM38 locus of two widely used Saccharomyces cerevisiae S288C strains, YPH499 and BY4742. Yeast 20(10):857-63
6) Ubiyvovk VM, et al.  (2006) Role of gamma-glutamyltranspeptidase in detoxification of xenobiotics in the yeasts Hansenula polymorpha and Saccharomyces cerevisiae. Cell Biol Int 30(8):665-71