ECL1/YGR146C Summary Help

Standard Name ECL1 1
Systematic Name YGR146C
Feature Type ORF, Verified
Description Protein of unknown function; mitochondrial-dependent role in the extension of chronological lifespan; overexpression increases oxygen consumption and respiratory activity while deletion results in reduced oxygen consumption under conditions of caloric restriction; induced by iron homeostasis transcription factor Aft2p; multicopy suppressor of temperature sensitive hsf1 mutant; induced by treatment with 8-methoxypsoralen and UVA irradiation (1, 2, 3, 4, 5)
Name Description Extends Chronological Lifespan 1
Chromosomal Location
ChrVII:784858 to 784223 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All ECL1 GO evidence and references
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 8 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
Resources
7 total interaction(s) for 6 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 2
  • Protein-RNA: 1
  • Two-hybrid: 2

Genetic Interactions
  • Dosage Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 211
Molecular Weight (Da) 23,996
Isoelectric Point (pI) 5.85
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:784858 to 784223 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..636 784858..784223 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003378
References cited on this page View Complete Literature Guide for ECL1
1) Azuma K, et al.  (2009) Identification and Characterization of an Ecl1-Family Gene in Saccharomyces cerevisiae. Biosci Biotechnol Biochem 73(12):2787-9
2) Rutherford JC, et al.  (2003) Aft1p and Aft2p mediate iron-responsive gene expression in yeast through related promoter elements. J Biol Chem 278(30):27636-43
3) Imazu H and Sakurai H  (2005) Saccharomyces cerevisiae heat shock transcription factor regulates cell wall remodeling in response to heat shock. Eukaryot Cell 4(6):1050-6
4) Dardalhon M, et al.  (2007) Specific transcriptional responses induced by 8-methoxypsoralen and UVA in yeast. FEMS Yeast Res 7(6):866-878
5) Azuma K, et al.  (2012) Extension of chronological lifespan by ScEcl1 depends on mitochondria in Saccharomyces cerevisiae. Biosci Biotechnol Biochem 76(10):1938-42