Standard Name	EAF7 1
Systematic Name	YNL136W
Feature Type	ORF, Verified
Description	Subunit of the NuA4 histone acetyltransferase complex, which acetylates the N-terminal tails of histones H4 and H2A (2)
Name Description	Esa1-Associated Factor 1

Chromosomal Location	ChrXIV:370368 to 371645 | ORF Map | GBrowse

	View Computational GO annotations for EAF7
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	DNA repair (IDA, IPI) histone acetylation (IPI) regulation of transcription from RNA polymerase II promoter (IMP, IPI)
Cellular Component
Manually curated	histone acetyltransferase complex (IDA) NuA4 histone acetyltransferase complex (IPI)
High-throughput	nucleus (IDA)

Classical genetics
null	inositol excretion: increased Ptr2p-GFP distribution: abnormal viable
Large-scale survey
null	acid pH resistance: decreased inositol excretion: increased competitive fitness: decreased dessication resistance: decreased haploproficient heat sensitivity: increased hyperosmotic stress resistance: decreased metal resistance: decreased nutrient utilization: increased resistance to ethanol: decreased resistance to nickel(2+): decreased resistance to mycophenolic acid: increased resistance to methyl methanesulfonate: increased resistance to caffeine: increased resistance to cycloheximide: increased resistance to camptothecin: increased resistance to bleomycin: increased resistance to cycloheximide: decreased resistance to amitrole: decreased resistance to quinine: decreased resistance to methyl methanesulfonate: decreased resistance to hydroxyurea: decreased resistance to sirolimus: decreased resistance to sodium selenide: decreased respiratory growth: decreased rate toxin resistance: decreased transposable element transposition: decreased vacuolar morphology: abnormal viable
overexpression	filamentous growth: increased resistance to sirolimus: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	577 total interaction(s) for 352 unique genes/features.
Physical Interactions	Affinity Capture-MS: 52 Affinity Capture-RNA: 2 Affinity Capture-Western: 5 Biochemical Activity: 8 Co-crystal Structure: 1
Genetic Interactions	Dosage Growth Defect: 32 Dosage Lethality: 5 Negative Genetic: 320 Positive Genetic: 22 Synthetic Growth Defect: 100 Synthetic Lethality: 25 Synthetic Rescue: 5
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIV:370368 to 371645 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1278 370368..371645 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005080