Standard Name	EAF6 1
Systematic Name	YJR082C
Feature Type	ORF, Verified
Description	Subunit of the NuA4 acetyltransferase complex that acetylates histone H4 and NuA3 acetyltransferase complex that acetylates histone H3 (1, 2)
Name Description	Esa1p-Associated Factor 1

Chromosomal Location	ChrX:582255 to 581914 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for EAF6
Molecular Function
Manually curated	contributes_to histone acetyltransferase activity (IC)
Biological Process
Manually curated	DNA repair (IDA) histone acetylation (IPI)
Cellular Component
Manually curated	NuA3 histone acetyltransferase complex (IDA) NuA4 histone acetyltransferase complex (IPI)
High-throughput	nucleus (IDA)

Large-scale survey
null	competitive fitness: decreased endocytosis: decreased resistance to caffeine: decreased resistance to camptothecin: decreased resistance to hydroxyurea: increased resistance to (S)-lactic acid: increased resistance to fenpropimorph: decreased resistance to fluconazole: decreased resistance to methyl methanesulfonate: decreased resistance to cycloheximide: decreased stress resistance: increased viable
overexpression	filamentous growth: increased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	202 total interaction(s) for 146 unique genes/features.
Physical Interactions	Affinity Capture-MS: 33 Affinity Capture-RNA: 3 Affinity Capture-Western: 1 Biochemical Activity: 1 Co-crystal Structure: 1 Co-purification: 1 Reconstituted Complex: 11 Two-hybrid: 11
Genetic Interactions	Dosage Growth Defect: 18 Negative Genetic: 54 Phenotypic Enhancement: 1 Positive Genetic: 16 Synthetic Growth Defect: 46 Synthetic Haploinsufficiency: 1 Synthetic Lethality: 4
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Mass Spec

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrX:582255 to 581914 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..342 582255..581914 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003842