EAF3/YPR023C Summary Help

Standard Name EAF3 1
Systematic Name YPR023C
Feature Type ORF, Verified
Description Component of the Rpd3S histone deacetylase complex; Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transposition (1, 2, 3)
Name Description Esa1p-Associated Factor 1
Chromosomal Location
ChrXVI:610031 to 608826 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All EAF3 GO evidence and references
  View Computational GO annotations for EAF3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 4 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
512 total interaction(s) for 251 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 80
  • Affinity Capture-RNA: 4
  • Affinity Capture-Western: 11
  • Co-crystal Structure: 1
  • Co-purification: 2
  • Protein-peptide: 2
  • Reconstituted Complex: 3
  • Two-hybrid: 3

Genetic Interactions
  • Dosage Growth Defect: 6
  • Dosage Rescue: 1
  • Negative Genetic: 227
  • Phenotypic Enhancement: 7
  • Phenotypic Suppression: 2
  • Positive Genetic: 50
  • Synthetic Growth Defect: 102
  • Synthetic Haploinsufficiency: 1
  • Synthetic Lethality: 5
  • Synthetic Rescue: 5

Resources
Expression Summary
histogram
Resources
Length (a.a.) 401
Molecular Weight (Da) 45,203
Isoelectric Point (pI) 8.43
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:610031 to 608826 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1206 610031..608826 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006227
References cited on this page View Complete Literature Guide for EAF3
1) Eisen A, et al.  (2001) The yeast NuA4 and Drosophila MSL complexes contain homologous subunits important for transcription regulation. J Biol Chem 276(5):3484-91
2) Carrozza MJ, et al.  (2005) Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription. Cell 123(4):581-92
3) Nyswaner KM, et al.  (2008) Chromatin-associated genes protect the yeast genome from ty1 insertional mutagenesis. Genetics 178(1):197-214