Standard Name	EAF1 1
Systematic Name	YDR359C
Alias	VID21 2
Feature Type	ORF, Verified
Description	Component of the NuA4 histone acetyltransferase complex; acts as a platform for assembly of NuA4 subunits into the native complex; required for initiation of pre-meiotic DNA replication, likely due to its requirement for expression of IME1 (3, 4, 5)
Name Description	Esa1p-Associated Factor 1

Chromosomal Location	ChrIV:1194884 to 1191936 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for EAF1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	cellular protein complex assembly (IMP) chromatin modification (IPI) DNA repair (IDA)
Cellular Component
Manually curated	histone acetyltransferase complex (IPI) NuA4 histone acetyltransferase complex (IPI)

Classical genetics
null	RPS11B mRNA accumulation: decreased X ray resistance: increased X ray resistance: decreased cell cycle progression through the G2/M phase transition: delayed tellurium atom accumulation: decreased glycogen accumulation: increased inositol excretion: increased heat sensitivity: increased meiosis: absent meiosis: abnormal carboxypeptidase Y (Prc1p) modification: decreased resistance to hydroxyurea: decreased resistance to methyl methanesulfonate: decreased resistance to 5-fluorouracil: decreased resistance to sirolimus: decreased vegetative growth: decreased
Large-scale survey
null	cell cycle progression through the G2/M phase transition: delayed cell size: increased glycogen accumulation: increased inositol excretion: increased competitive fitness: decreased dessication resistance: decreased haploinsufficient haploproficient heat sensitivity: increased ionic stress resistance: decreased oxidative stress resistance: decreased resistance to camptothecin: decreased resistance to arsenite(3-): decreased resistance to nickel sulfate: decreased resistance to methyl methanesulfonate: decreased resistance to 5-fluorouracil: decreased resistance to monensin: decreased resistance to tunicamycin: increased resistance to sirolimus: increased resistance to mycophenolic acid: increased resistance to fenpropimorph: increased resistance to (S)-lactic acid: increased resistance to hydroxyurea: decreased resistance to sirolimus: decreased resistance to acetic acid: decreased resistance to bleomycin: decreased resistance to caffeine: decreased resistance to fluconazole: decreased resistance to dimethyl sulfoxide: decreased resistance to hygromycin B: decreased resistance to sorbate: decreased resistance to benzo[a]pyrene: decreased sporulation: decreased stress resistance: increased vacuolar morphology: abnormal vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	718 total interaction(s) for 465 unique genes/features.
Physical Interactions	Affinity Capture-MS: 66 Affinity Capture-RNA: 2 Affinity Capture-Western: 35 Co-crystal Structure: 7 Co-localization: 1 Co-purification: 1 Two-hybrid: 6
Genetic Interactions	Dosage Growth Defect: 31 Dosage Lethality: 27 Dosage Rescue: 1 Negative Genetic: 130 Phenotypic Enhancement: 1 Positive Genetic: 73 Synthetic Growth Defect: 237 Synthetic Lethality: 95 Synthetic Rescue: 5
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:1194884 to 1191936 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 2004-02-06
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2949 1194884..1191936 2011-02-03 2004-02-06
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002767