Standard Name	DER1 1
Systematic Name	YBR201W
Feature Type	ORF, Verified
Description	Endoplasmic reticulum membrane protein, required for ER-associated protein degradation of misfolded or unassembled proteins; N- and C- termini protrude into the cytoplasm, has similarity to Dfm1p (1, 2, 3)
Name Description	Degradation in the Endoplasmic Reticulum 1

Chromosomal Location	ChrII:623576 to 624211 | ORF Map | GBrowse

	View Computational GO annotations for DER1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	ER-associated protein catabolic process (IMP, IPI)
Cellular Component
Manually curated	endoplasmic reticulum membrane (IDA) Hrd1p ubiquitin ligase ERAD-L complex (IDA)
High-throughput	integral to membrane (ISM)

Classical genetics
null	prion formation: increased viable
Large-scale survey
null	competitive fitness: increased resistance to cycloheximide: decreased resistance to sorbate: increased resistance to quinine: decreased resistance to clioquinol: decreased starvation resistance: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	198 total interaction(s) for 126 unique genes/features.
Physical Interactions	Affinity Capture-MS: 10 Affinity Capture-Western: 17 Two-hybrid: 1
Genetic Interactions	Negative Genetic: 112 Phenotypic Enhancement: 13 Phenotypic Suppression: 8 Positive Genetic: 34 Synthetic Growth Defect: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrII:623576 to 624211 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1999-04-26
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..636 623576..624211 2011-02-03 1999-04-26
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000405