DYS1/YHR068W Summary

DYS1 BASIC INFORMATION

Standard Name	DYS1
Systematic Name	YHR068W
Feature Type	ORF, Verified
Description	Deoxyhypusine synthase, catalyzes formation of deoxyhypusine, the first step in hypusine biosynthesis; triggers posttranslational hypusination of translation elongation factor eIF-5A and regulates its intracellular levels; tetrameric (1, 2, 3)
Name Description	DeoxyhYpusine Synthase

GO Annotations	All DYS1 GO evidence and references
	View Computational GO annotations for DYS1
Molecular Function
Manually curated	transferase activity, transferring alkyl or aryl (other than methyl) groups (IDA)
Biological Process
Manually curated	peptidyl-lysine modification to hypusine (IDA)
Cellular Component
High-throughput	cytoplasm (IDA)

Mutant Phenotype	All DYS1 Phenotype details and references
Large-scale survey
null	inviable
repressible	cell cycle progression in G1 phase: abnormal

Interactions	DYS1 All interactions details and references
	11 total interaction(s) for 8 unique genes/features.
Physical Interactions	Affinity Capture-MS: 2 Affinity Capture-Western: 2 Biochemical Activity: 1 PCA: 1 Two-hybrid: 5

Sequence Information

ChrVIII:232135 to 233298 | |

Last Update

Coordinates: 2005-11-07 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1164	232135..233298	2005-11-07	1996-07-31

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000001110

DYS1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for DYS1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for DYS1]

1)	Kang KR, et al. (1995) Identification of YHR068w in Saccharomyces cerevisiae chromosome VIII as a gene for deoxyhypusine synthase. Expression and characterization of the enzyme. J Biol Chem 270(31):18408-12
2)	Abid R, et al. (1997) Novel features of the functional site and expression of the yeast deoxyhypusine synthase. Biol Signals 6(3):157-65
3)	Thompson GM, et al. (2003) Mapping eIF5A binding sites for Dys1 and Lia1: in vivo evidence for regulation of eIF5A hypusination. FEBS Lett 555(3):464-8

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