DYN1/YKR054C Summary Help

Standard Name DYN1 1
Systematic Name YKR054C
Alias DHC1 2 , PAC6
Feature Type ORF, Verified
Description Cytoplasmic heavy chain dynein; microtubule motor protein; member of the AAA+ protein family, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p; motility along microtubules inhibited by She1p (1, 2, 3, 4, 5, 6)
Name Description DYNein 1
Chromosomal Location
ChrXI:547925 to 535647 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Genetic position: 24.6 cM
Gene Ontology Annotations All DYN1 GO evidence and references
  View Computational GO annotations for DYN1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 5 genes
Classical genetics
reduction of function
Large-scale survey
415 total interaction(s) for 227 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 6
  • Affinity Capture-RNA: 1
  • Co-crystal Structure: 2
  • Co-fractionation: 1
  • Co-localization: 7
  • Co-purification: 3
  • FRET: 1
  • PCA: 2
  • Reconstituted Complex: 9
  • Two-hybrid: 104

Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Rescue: 4
  • Negative Genetic: 155
  • Phenotypic Enhancement: 18
  • Phenotypic Suppression: 8
  • Positive Genetic: 9
  • Synthetic Growth Defect: 29
  • Synthetic Lethality: 51
  • Synthetic Rescue: 4

Expression Summary
Length (a.a.) 4,092
Molecular Weight (Da) 471,343
Isoelectric Point (pI) 6.21
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrXI:547925 to 535647 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Genetic position: 24.6 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..12279 547925..535647 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001762
References cited on this page View Complete Literature Guide for DYN1
1) Eshel D, et al.  (1993) Cytoplasmic dynein is required for normal nuclear segregation in yeast. Proc Natl Acad Sci U S A 90(23):11172-6
2) Li YY, et al.  (1993) Disruption of mitotic spindle orientation in a yeast dynein mutant. Proc Natl Acad Sci U S A 90(21):10096-100
3) Saunders WS, et al.  (1995) Saccharomyces cerevisiae kinesin- and dynein-related proteins required for anaphase chromosome segregation. J Cell Biol 128(4):617-24
4) Steinberg-Neifach O and Eshel D  (2000) Simultaneous expression of both MAT loci in haploid cells suppresses mutations in yeast microtubule motor genes. Mol Gen Genet 264(3):300-5
5) Lee WL, et al.  (2003) The role of the lissencephaly protein Pac1 during nuclear migration in budding yeast. J Cell Biol 160(3):355-64
6) Markus SM, et al.  (2012) She1-mediated inhibition of dynein motility along astral microtubules promotes polarized spindle movements. Curr Biol 22(23):2221-30