DYN1/YKR054C Summary Help

DYN1 BASIC INFORMATION

Standard Name DYN1 1
Systematic Name YKR054C
Alias DHC1 2 , PAC6
Feature Type ORF, Verified
Description Cytoplasmic heavy chain dynein, microtubule motor protein, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p (1, 2, 3, 4, 5)
Name Description DYNein 1
GO Annotations All DYN1 GO evidence and references
    View Computational GO annotations for DYN1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All DYN1 Phenotype details and references
Classical genetics
reduction of function
Large-scale survey
null
Interactions DYN1 All interactions details and references
114 total interaction(s) for 62 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 5
  • Two-hybrid: 12
Genetic Interactions
  • Dosage Rescue: 2
  • Phenotypic Enhancement: 25
  • Phenotypic Suppression: 4
  • Synthetic Growth Defect: 6
  • Synthetic Lethality: 58
  • Synthetic Rescue: 2
Sequence Information
ChrXI:547567 to 535289 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Genetic position: 24.6 cM
Last Update Coordinates: 2005-12-15 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..12279 547567..535289 2005-12-15 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000001762

DYN1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Literature
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  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
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  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for DYN1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for DYN1]

1) Eshel D, et al.  (1993) Cytoplasmic dynein is required for normal nuclear segregation in yeast. Proc Natl Acad Sci U S A 90(23):11172-6
2) Li YY, et al.  (1993) Disruption of mitotic spindle orientation in a yeast dynein mutant. Proc Natl Acad Sci U S A 90(21):10096-100
3) Saunders WS, et al.  (1995) Saccharomyces cerevisiae kinesin- and dynein-related proteins required for anaphase chromosome segregation. J Cell Biol 128(4):617-24
4) Steinberg-Neifach O and Eshel D  (2000) Simultaneous expression of both MAT loci in haploid cells suppresses mutations in yeast microtubule motor genes. Mol Gen Genet 264(3):300-5
5) Lee WL, et al.  (2003) The role of the lissencephaly protein Pac1 during nuclear migration in budding yeast. J Cell Biol 160(3):355-64