DSS4/YPR017C Summary Help

Standard Name DSS4 1
Systematic Name YPR017C
Feature Type ORF, Verified
Description Guanine nucleotide dissociation stimulator for Sec4p; functions in the post-Golgi secretory pathway; binds zinc, found both on membranes and in the cytosol (2, 3, 4)
Name Description Dominant Suppressor of Sec4 1
Chromosomal Location
ChrXVI:593917 to 593486 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All DSS4 GO evidence and references
  View Computational GO annotations for DSS4
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 2 genes
Resources
Large-scale survey
null
Resources
49 total interaction(s) for 34 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 9
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 2
  • Biochemical Activity: 1
  • Reconstituted Complex: 1
  • Two-hybrid: 4

Genetic Interactions
  • Dosage Rescue: 3
  • Negative Genetic: 11
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 11
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 143
Molecular Weight (Da) 16,126
Isoelectric Point (pI) 5.04
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:593917 to 593486 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..432 593917..593486 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006221
References cited on this page View Complete Literature Guide for DSS4
1) Novick P, et al.  (1993) The cycle of SEC4 function in vesicular transport. Ciba Found Symp 176:218-28; discussion 229-32
2) Jiang Y, et al.  (1998) A high copy suppressor screen reveals genetic interactions between BET3 and a new gene. Evidence for a novel complex in ER-to-Golgi transport. Genetics 149(2):833-41
3) Moya M, et al.  (1993) DSS4-1 is a dominant suppressor of sec4-8 that encodes a nucleotide exchange protein that aids Sec4p function. Nature 361(6411):460-3
4) Collins RN, et al.  (1997) Interactions of nucleotide release factor Dss4p with Sec4p in the post-Golgi secretory pathway of yeast. J Biol Chem 272(29):18281-9