DSK2/YMR276W Summary Help

DSK2 BASIC INFORMATION

Standard Name DSK2 1
Systematic Name YMR276W
Feature Type ORF, Verified
Description Nuclear-enriched ubiquitin-like polyubiquitin-binding protein, required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle, involved in proteolysis, interacts with the proteasome (2, 3, 4, 5, 6, 7)
GO Annotations All DSK2 GO evidence and references
    View Computational GO annotations for DSK2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All DSK2 Phenotype details and references
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Interactions DSK2 All interactions details and references
  View additional details at BioGRID
93 total interaction(s) for 59 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 11
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 12
  • Biochemical Activity: 1
  • Co-crystal Structure: 1
  • Co-purification: 1
  • Far Western: 1
  • Reconstituted Complex: 4
  • Two-hybrid: 12
Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 14
  • Phenotypic Enhancement: 5
  • Phenotypic Suppression: 2
  • Positive Genetic: 5
  • Synthetic Growth Defect: 16
  • Synthetic Rescue: 6
Sequence Information
ChrXIII:818826 to 819947 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2004-02-27 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1122 818826..819947 2004-02-27 1996-07-31
Post-translational Modifications PhosphoGRID | PhosphoPep Database
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000004889

DSK2 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for DSK2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for DSK2]

1) Vallen EA, et al.  (1994) Genetic interactions between CDC31 and KAR1, two genes required for duplication of the microtubule organizing center in Saccharomyces cerevisiae. Genetics 137(2):407-22
2) Biggins S, et al.  (1996) Yeast ubiquitin-like genes are involved in duplication of the microtubule organizing center. J Cell Biol 133(6):1331-46
3) Khalfan W, et al.  (2000) Functional interaction between the PKC1 pathway and CDC31 network of SPB duplication genes. Genetics 155(4):1543-59
4) Kaye FJ, et al.  (2000) A family of ubiquitin-like proteins binds the ATPase domain of Hsp70-like Stch. FEBS Lett 467(2-3):348-55
5) Funakoshi M, et al.  (2002) Budding yeast Dsk2p is a polyubiquitin-binding protein that can interact with the proteasome. Proc Natl Acad Sci U S A 99(2):745-50
6) Rao H and Sastry A  (2002) Recognition of specific ubiquitin conjugates is important for the proteolytic functions of the ubiquitin-associated domain proteins Dsk2 and Rad23. J Biol Chem 277(14):11691-5
7) Saeki Y, et al.  (2002) Ubiquitin-like proteins and Rpn10 play cooperative roles in ubiquitin-dependent proteolysis. Biochem Biophys Res Commun 293(3):986-92