Standard Name	DSK2 1
Systematic Name	YMR276W
Feature Type	ORF, Verified
Description	Nuclear-enriched ubiquitin-like polyubiquitin-binding protein; required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle; involved in proteolysis; interacts with the proteasome; protein abundance increases in response to DNA replication stress (2, 3, 4, 5, 6, 7, 8)

Chromosomal Location	ChrXIII:818827 to 819948 | ORF Map | GBrowse

	View Computational GO annotations for DSK2
Molecular Function
Manually curated	protein binding, bridging (IMP, IPI)
Biological Process
Manually curated	ER-associated protein catabolic process (IMP) spindle pole body duplication associated with nuclear envelope (IGI)
Cellular Component
Manually curated	nucleus (IC)

Classical genetics
null	metal resistance: decreased Fbp1p accumulation: increased viable
overexpression	budding: abnormal inviable polyubiquitin accumulation: increased
Large-scale survey
null	auxotrophy competitive fitness: increased haploinsufficient resistance to glycolaldehyde: decreased starvation resistance: decreased stress resistance: decreased vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased rate vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	118 total interaction(s) for 67 unique genes/features.
Physical Interactions	Affinity Capture-MS: 13 Affinity Capture-RNA: 2 Affinity Capture-Western: 25 Biochemical Activity: 1 Co-crystal Structure: 1 Co-purification: 1 Far Western: 1 Reconstituted Complex: 8 Two-hybrid: 13
Genetic Interactions	Dosage Growth Defect: 10 Dosage Lethality: 1 Dosage Rescue: 1 Negative Genetic: 14 Phenotypic Enhancement: 5 Phenotypic Suppression: 4 Positive Genetic: 5 Synthetic Growth Defect: 6 Synthetic Rescue: 7
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIII:818827 to 819948 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1122 818827..819948 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004889