Standard Name	DPH2 1
Systematic Name	YKL191W
Feature Type	ORF, Verified
Description	Protein required, along with Dph1p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph1p and Kti11p (2, 3, 4)
Name Description	DiPHthamide 2

Chromosomal Location	ChrXI:81035 to 82639 | ORF Map | GBrowse

	View Computational GO annotations for DPH2
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	peptidyl-diphthamide biosynthetic process from peptidyl-histidine (IMP)
Cellular Component
High-throughput	cytoplasm (IDA)

Pathways	diphthamide biosynthesis

Classical genetics
null	resistance to sordarin: increased resistance to tellurite: increased
unspecified	toxin resistance: increased
Large-scale survey
null	competitive fitness: decreased haploinsufficient resistance to nickel sulfate: decreased resistance to arsenite(3-): decreased resistance to caffeine: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	42 total interaction(s) for 31 unique genes/features.
Physical Interactions	Affinity Capture-MS: 16 Affinity Capture-Western: 2 Biochemical Activity: 2 PCA: 1 Two-hybrid: 2
Genetic Interactions	Negative Genetic: 12 Positive Genetic: 1 Synthetic Growth Defect: 6
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXI:81035 to 82639 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1605 81035..82639 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001674