Standard Name	DPB2 1
Systematic Name	YPR175W
Feature Type	ORF, Verified
Description	Second largest subunit of DNA polymerase II (DNA polymerase epsilon), required for maintenance of fidelity of chromosomal replication; expression peaks at the G1/S phase boundary; Cdc28p substrate (1, 2, 3)
Name Description	DNA Polymerase B subunit 2 1

Chromosomal Location	ChrXVI:888974 to 891043 | ORF Map | GBrowse

	View Computational GO annotations for DPB2
Molecular Function
Manually curated	contributes_to DNA-directed DNA polymerase activity (IDA) contributes_to double-stranded DNA binding (IDA) contributes_to single-stranded DNA binding (IDA)
Biological Process
Manually curated	DNA-dependent DNA replication (IDA) error-prone translesion synthesis (IDA, IMP) heterochromatin organization involved in chromatin silencing (IC) maintenance of fidelity involved in DNA-dependent DNA replication (IMP)
Cellular Component
Manually curated	cytoplasm (IDA) epsilon DNA polymerase complex (IDA) nucleus (IDA)

Classical genetics
conditional	cell shape: abnormal vegetative growth: decreased rate
null	inviable
Large-scale survey
null	inviable
reduction of function	competitive fitness: increased
repressible	cell cycle progression in S phase: abnormal chromosome/plasmid maintenance: decreased
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	119 total interaction(s) for 57 unique genes/features.
Physical Interactions	Affinity Capture-MS: 52 Affinity Capture-Western: 23 Biochemical Activity: 2 Co-crystal Structure: 1 Co-fractionation: 1 Co-purification: 3 Reconstituted Complex: 3 Two-hybrid: 18
Genetic Interactions	Dosage Rescue: 3 Negative Genetic: 2 Phenotypic Enhancement: 3 Phenotypic Suppression: 2 Synthetic Growth Defect: 2 Synthetic Lethality: 4
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXVI:888974 to 891043 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 2003-09-22
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2070 888974..891043 2011-02-03 2003-09-22
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000006379