Standard Name	DOT5 1
Systematic Name	YIL010W
Feature Type	ORF, Verified
Description	Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth (2)
Name Description	Disruptor Of Telomeric silencing 1

Chromosomal Location	ChrIX:334882 to 335529 | ORF Map | GBrowse

	View Computational GO annotations for DOT5
Molecular Function
Manually curated	thioredoxin peroxidase activity (IDA, IMP, ISS)
Biological Process
Manually curated	cell redox homeostasis (IDA, IMP) cellular response to oxidative stress (IGI)
Cellular Component
Manually curated	nucleus (IDA, ISS)

Classical genetics
null	oxidative stress resistance: decreased
overexpression	silencing: decreased telomere length: increased
Large-scale survey
null	competitive fitness: decreased haploproficient resistance to sodium selenide: decreased resistance to 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid: decreased starvation resistance: decreased vacuolar morphology: abnormal viable
overexpression	silencing: decreased vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	33 total interaction(s) for 31 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 2 Biochemical Activity: 3 Reconstituted Complex: 3 Two-hybrid: 2
Genetic Interactions	Dosage Growth Defect: 4 Negative Genetic: 15 Phenotypic Enhancement: 1 Positive Genetic: 2 Synthetic Growth Defect: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIX:334882 to 335529 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1994-12-10
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..648 334882..335529 2011-02-03 1994-12-10
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001272