DIP5/YPL265W Summary Help

Standard Name DIP5
Systematic Name YPL265W
Feature Type ORF, Verified
Description Dicarboxylic amino acid permease; mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate; also a transporter for Gln, Asn, Ser, Ala, and Gly; relocalizes from plasma membrane to vacuole upon DNA replication stress (1, 2, 3)
Name Description DIcarboxylic amino acid Permease
Chromosomal Location
ChrXVI:41043 to 42869 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All DIP5 GO evidence and references
  View Computational GO annotations for DIP5
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 21 genes
Resources
Large-scale survey
null
overexpression
Resources
67 total interaction(s) for 60 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 8
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 1
  • PCA: 24
  • Protein-RNA: 1

Genetic Interactions
  • Negative Genetic: 19
  • Phenotypic Enhancement: 3
  • Phenotypic Suppression: 2
  • Positive Genetic: 3
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 608
Molecular Weight (Da) 68,097
Isoelectric Point (pI) 9.55
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:41043 to 42869 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1827 41043..42869 1996-07-31 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | TCDB | UniProtKB
Primary SGDIDS000006186
References cited on this page View Complete Literature Guide for DIP5
1) Regenberg B, et al.  (1999) Substrate specificity and gene expression of the amino-acid permeases in Saccharomyces cerevisiae. Curr Genet 36(6):317-28
2) Regenberg B, et al.  (1998) Dip5p mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate in Saccharomyces cerevisiae. Curr Genet 33(3):171-7
3) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76