DFG10/YIL049W Summary Help

Standard Name DFG10 1
Systematic Name YIL049W
Feature Type ORF, Verified
Description Probable polyprenol reductase; catalyzes conversion of polyprenol to dolichol, the precursor for N-glycosylation; involved in filamentous growth; mutations in human ortholog SRD5A3 confer CDG (Congenital Disorders of Glycosylation) (1, 2)
Name Description Defective for Filamentous Growth 1
Chromosomal Location
ChrIX:260158 to 260919 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All DFG10 GO evidence and references
  View Computational GO annotations for DFG10
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 1 genes
Resources
Classical genetics
null
unspecified
Large-scale survey
null
Resources
12 total interaction(s) for 12 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 2

Genetic Interactions
  • Negative Genetic: 1
  • Phenotypic Suppression: 3
  • Positive Genetic: 1
  • Synthetic Growth Defect: 3
  • Synthetic Haploinsufficiency: 1
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 253
Molecular Weight (Da) 30,305
Isoelectric Point (pI) 9.93
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIX:260158 to 260919 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1994-12-10
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..762 260158..260919 2011-02-03 1994-12-10
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001311
References cited on this page View Complete Literature Guide for DFG10
1) Mosch HU and Fink GR  (1997) Dissection of filamentous growth by transposon mutagenesis in Saccharomyces cerevisiae. Genetics 145(3):671-84
2) Cantagrel V, et al.  (2010) SRD5A3 is required for converting polyprenol to dolichol and is mutated in a congenital glycosylation disorder. Cell 142(2):203-17