DER1/YBR201W Summary Help

Standard Name DER1 1
Systematic Name YBR201W
Feature Type ORF, Verified
Description ER membrane protein that promotes export of misfolded polypeptides; required for ER-associated protein degradation of misfolded or unassembled proteins; initiates export of aberrant polypeptides from ER lumen by threading them into the ER membrane and routing them to Hrd1p for ubiquitylation; N- and C- termini protrude into the cytoplasm; similar to Dfm1p; homolog of mammalian derlin-1 (1, 2, 3, 4)
Name Description Degradation in the Endoplasmic Reticulum 1
Chromosomal Location
ChrII:623576 to 624211 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All DER1 GO evidence and references
  View Computational GO annotations for DER1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 4 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
207 total interaction(s) for 127 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 10
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 24
  • Two-hybrid: 1

Genetic Interactions
  • Negative Genetic: 113
  • Phenotypic Enhancement: 13
  • Phenotypic Suppression: 8
  • Positive Genetic: 34
  • Synthetic Growth Defect: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 211
Molecular Weight (Da) 24,391
Isoelectric Point (pI) 8.35
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrII:623576 to 624211 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1999-04-26
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..636 623576..624211 2011-02-03 1999-04-26
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000405
References cited on this page View Complete Literature Guide for DER1
1) Knop M, et al.  (1996) Der1, a novel protein specifically required for endoplasmic reticulum degradation in yeast. EMBO J 15(4):753-63
2) Sommer T and Wolf DH  (1997) Endoplasmic reticulum degradation: reverse protein flow of no return. FASEB J 11(14):1227-33
3) Hitt R and Wolf DH  (2004) Der1p, a protein required for degradation of malfolded soluble proteins of the endoplasmic reticulum: topology and Der1-like proteins. FEMS Yeast Res 4(7):721-9
4) Mehnert M, et al.  (2014) Der1 promotes movement of misfolded proteins through the endoplasmic reticulum membrane. Nat Cell Biol 16(1):77-86