DED1/YOR204W Summary Help

DED1 BASIC INFORMATION

Standard Name DED1
Systematic Name YOR204W
Alias SPP81
Feature Type ORF, Verified
Description ATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase, required for translation initiation of all yeast mRNAs; mutations in human DEAD-box DBY are a frequent cause of male infertility (1, 2, 3)
Name Description DEaD-box protein
GO Annotations All DED1 GO evidence and references
    View Computational GO annotations for DED1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All DED1 Phenotype details and references
Large-scale survey
null
Interactions DED1 All interactions details and references
133 total interaction(s) for 112 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 95
  • Affinity Capture-Western: 2
  • Biochemical Activity: 2
  • Co-purification: 1
  • PCA: 8
Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 8
  • Phenotypic Suppression: 1
  • Synthetic Growth Defect: 7
  • Synthetic Lethality: 4
  • Synthetic Rescue: 4
Sequence Information
ChrXV:722912 to 724726 | ORF Map | GBrowse
Gbrowse
Genetic position: 114 cM
Last Update Coordinates: 2006-01-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1815 722912..724726 2006-01-05 1996-07-31
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000005730

DED1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for DED1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for DED1]

1) Iost I, et al.  (1999) Ded1p, a DEAD-box protein required for translation initiation in Saccharomyces cerevisiae, is an RNA helicase. J Biol Chem 274(25):17677-83
2) Noueiry AO, et al.  (2000) A mutant allele of essential, general translation initiation factor DED1 selectively inhibits translation of a viral mRNA. Proc Natl Acad Sci U S A 97(24):12985-90
3) Johnstone O, et al.  (2005) Belle is a Drosophila DEAD-box protein required for viability and in the germ line. Dev Biol 277(1):92-101