DDR48/YMR173W Summary

DDR48/YMR173W Summary

Standard Name	DDR48
Systematic Name	YMR173W
Feature Type	ORF, Verified
Description	DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; protein abundance increases in response to DNA replication stress (1, 2) Also known as: FSP
Name Description	DNA Damage Responsive 3

Chromosomal Location	ChrXIII:608689 to 609981 \| ORF Map \| GBrowse

Gene Ontology Annotations All DDR48 GO evidence and references

	View Computational GO annotations for DDR48
Molecular Function
Manually curated	ATPase activity (IDA) GTPase activity (IDA)
Biological Process
Manually curated	DNA repair (IDA, IMP)
Cellular Component
High-throughput	cytoplasm (IDA)

Mutant phenotypes All DDR48 Phenotype evidence and references

Classical genetics
null	metal resistance: increased
overexpression	TBSV replicon RNA (repRNA) accumulation: decreased
Large-scale survey
null	competitive fitness: increased haploinsufficient hyperosmotic stress resistance: decreased starvation resistance: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY \| SCMD \| ScreenTroll \| Yeast Fitness Database

interactions All DDR48 Interaction evidence and references

	42 total interaction(s) for 42 unique genes/features.
Physical Interactions	Affinity Capture-MS: 13 Affinity Capture-RNA: 1 Biochemical Activity: 8
Genetic Interactions	Negative Genetic: 18 Positive Genetic: 2
Resources	BioGRID \| BOND \| BioPIXIE \| CYC2008 (complexes) \| Complexome \| DIP \| DRYGIN \| GeneMANIA \| InterologFinder

Expression Summary


Resources	Expression Summary \| Cell cycle and metabolic oscillation \| Cell cycle transcript profile \| Cyclebase \| Genevestigator \| GermOnline \| SPELL \| YMGV \| YeastFunc

Protein Information All DDR48 Protein evidence and references

Localization	YeastRC \| Organelle DB (UMich) \| YPL+ \| YeastGFP
Phosphorylation	PhosphoGRID \| PhosphoPep Database
Structure	GPMDB \| SCOP \| YeastRC
Homologs	Ashbya (AGD) \| Fungal Orthogroups Repository \| P-POD \| PDB Homologs \| PhylomeDB \| YGOB \| YOGY

sequence information

ChrXIII:608689 to 609981 | |

SGD ORF map

Last Update

Coordinates: 2011-02-03 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1293	608689..609981	2011-02-03	1996-07-31

Retrieve sequences

Analyze Sequence

S288C only	BLASTP \| ATCC/WashU Clones \| BLASTN \| Design Primers \| Restriction Fragment Map \| Restriction Fragment Sizes \| Six-Frame Translation
S288C vs. other species	Fungal Alignment \| BLASTN vs. fungi \| BLASTP at NCBI \| BLASTP vs. fungi \| Synteny Viewer
S288C vs. other strains	Strain Alignment

Resources

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| Search all NCBI (Entrez) \| UniProtKB

Primary SGDID	S000004784

References cited on this page View Complete Literature Guide for DDR48

1)	Treger JM and McEntee K (1990) Structure of the DNA damage-inducible gene DDR48 and evidence for its role in mutagenesis in Saccharomyces cerevisiae. Mol Cell Biol 10(6):3174-84
2)	Tkach JM, et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
3)	Maga JA, et al. (1986) Transcriptional regulation of DNA damage responsive (DDR) genes in different rad mutant strains of Saccharomyces cerevisiae. Mol Gen Genet 205(2):276-84